Hyponatraemia

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Hyponatraemia sive hyponatriaemia (ICD-10: E87.1) est in medicina minor (hypo-) natrii concentratio (-natr(i)-) in sanguine (-aemia)[1] et frequentissima electrolytorum perturbationum[2]. Symptomata multipliciter esse possunt. Haec perturbatio parvo valore (< 135 mmol/L) in sanguine aestimatur. Causae hyponatraemiae sunt, per exemplum, consumptio diureticorum (ut thiazidi), aetas (senectus), hypoglykaemia, diabetes mellitus, consumptio inhibitorum enzymi angiotensinum convertentes, oesophagitis, infectiones systematis urogenitalis.[3]

Correctio hyponatraemiae diligenter fienda est; si quae enim nimis cito peragatur, in cerebro myelinolysis pontina centralis periculosa oriatur.

Concentrationis nimis natrii vocatur hypernatraemia.

Physiologia

In corpore humano et pondere 70 chiliogrammatum circiter 100 g natrii insunt.[4]. Valor natrii normalis in sanguine est 135–145 mmol/l.

Hyponatraemia medicamentis causa

Consumptio non solum diureticorum (thiazidorum), sed etiam inhibitorum reabsorptionis serotonini selectivorum (SSRI) atque Venlafaxini hyponatraemiam contrahere potest[5].

Notae

  1. Williams D. M., Gallagher M., Handley J., Stephens J. W. (Iul 2016). "The clinical management of hyponatraemia". Postgraduate Medical Journal 92 (1089): 407–11 
  2. Upadhyay A., Jaber B. L., Madias N. E. (Iul 2006). "Incidence and prevalence of hyponatremia". American Journal of Medicine 119 (suppl 1): S30-5 
  3. Rastogi D., Pelter M. A., Deamer R. L. (Mar 2012). "Evaluations of Hospitalizations Associated With Thiazide-Associated Hyponatremia". J Clin Hypertensio 14: 158–64 
  4. W. Kaim, B. Schwederski: Bioanorganische Chemie. 4. Auflage. Teubner, Wiesbaden 2005, ISBN 3-519-33505-0. (Theodisce)
  5. Romero S., Pintor L., Serra M., Plana T., Navarro V., Gastó C., Goldstein B. (2007). "Syndrome of inappropriate secretion of antidiuretic hormone due to citalopram and venlafaxine". General hospital psychiatry 29 (1): 81–4 

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