セロトニントランスポーター遺伝子

SLC6A4
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I74

識別子
記号SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR
外部IDOMIM: 182138 MGI: 96285 HomoloGene: 817 GeneCards: SLC6A4
遺伝子の位置 (ヒト)
17番染色体 (ヒト)
染色体17番染色体 (ヒト)[1]
17番染色体 (ヒト)
SLC6A4遺伝子の位置
SLC6A4遺伝子の位置
バンドデータ無し開始点30,194,319 bp[1]
終点30,236,002 bp[1]
遺伝子の位置 (マウス)
11番染色体 (マウス)
染色体11番染色体 (マウス)[2]
11番染色体 (マウス)
SLC6A4遺伝子の位置
SLC6A4遺伝子の位置
バンドデータ無し開始点76,889,429 bp[2]
終点76,923,166 bp[2]
RNA発現パターン
さらなる参照発現データ
遺伝子オントロジー
分子機能 cocaine binding
nitric-oxide synthase binding
protein homodimerization activity
myosin binding
syntaxin-1 binding
金属イオン結合
neurotransmitter:sodium symporter activity
actin filament binding
monoamine transmembrane transporter activity
血漿タンパク結合
symporter activity
serotonin:sodium symporter activity
dopamine:sodium symporter activity
serotonin binding
細胞の構成要素 integral component of membrane
細胞質基質
エンドソーム

integral component of plasma membrane
脂質ラフト
neuron projection
endosome membrane
細胞内膜系
presynapse
細胞膜
integral component of postsynaptic membrane
integral component of presynaptic membrane
serotonergic synapse
焦点接着
シナプス
生物学的プロセス 有機物への細胞応答
cellular response to retinoic acid
エストラジオールへの反応
cellular response to cGMP
低酸素症への反応
negative regulation of neuron differentiation
射精
response to nutrient
血管収縮
negative regulation of cerebellar granule cell precursor proliferation
記憶
monoamine transport
有機物への反応
脳発生
positive regulation of gene expression
positive regulation of cell cycle
serotonin transport
protein complex oligomerization
概日リズム
膜貫通輸送
社会的行動
serotonin uptake
神経伝達物質の輸送
negative regulation of organ growth
protein homooligomerization
毒性物質への反応
negative regulation of synaptic transmission, dopaminergic
brain morphogenesis
positive regulation of serotonin secretion
神経伝達物質生合成プロセス
dopamine uptake involved in synaptic transmission
regulation of thalamus size
出典:Amigo / QuickGO
オルソログ
ヒトマウス
Entrez
Ensembl
UniProt
RefSeq
(mRNA)

NM_001045

NM_010484

RefSeq
(タンパク質)

NP_001036

NP_034614

場所
(UCSC)
Chr 17: 30.19 – 30.24 MbChr 17: 76.89 – 76.92 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

セロトニントランスポーター遺伝子(セロトニントランスポーターいでんし)とは、神経伝達物質であるセロトニンの伝達に関係する遺伝情報が書き込まれた遺伝子である。染色体番号17に存在する。組み合わせはSS型、SL型、LL型がある。

1996年11月、ヴュルツブルク大学精神医学部のペーター・レッシュ(PETER LESCH)らがS型がセロトニン分泌に関与すると発表[5]

この遺伝子型を持つ者の割合は民族によって異なる。日本人はS型保有傾向が欧米人に比べ5割も多い代わり、LL型保有者は2%と世界で最も少ない。傾向としては、アフリカ > ヨーロッパ > アジアの順番で、LL型が減少する[6]

参照

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108576 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020838 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ Klaus-Peter Lesch; 共Dietmar Bengel, Armin Heils, Sue Z. Sabol, Benjamin D. Greenberg, Susanne Petri, Jonathan Benjamin, Clemens R. Müller, Dean H. Hamer, Dennis L. Murphy (11 1996). “Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region”. サイエンス (サイエンス) 274 (5292): 1527-1531. doi:10.1126/science.274.5292.1527. ISSN 1095-9203. http://www.sciencemag.org/content/274/5292/1527 2012年2月5日閲覧。. 
  6. ^ 血液型より正確!? あなたの性格はDNAで決まっていた(週刊現代) @gendai_biz”. 現代ビジネス. 2020年10月28日閲覧。

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