Sirukumab

Sirukumab
Nomi alternativi
CNTO-136, Plivensia
Caratteristiche generali
Formula bruta o molecolareC6450H9926N1690O1998S46
Massa molecolare (u)144 588,95
Numero CAS1194585-53-9
DrugBankDBDB11803
Dati farmacocinetici
Legame proteicocon l'interleuchina 6
Indicazioni di sicurezza
Modifica dati su Wikidata · Manuale

Il sirukumab (CNTO-136, conosciuto con il nome commerciale di Plivensia) è un anticorpo monoclonale umano progettato per il trattamento dell'artrite reumatoide;[1] l'anticorpo agisce contro la molecola proinfiammatoria interleuchina 6, una citochina.[2]

Attualmente il sirukumab viene prodotto dalla casa farmaceutica Centocor, sussidiaria della Johnson & Johnson.[3]

Studi clinici

Il sirukumab è stato impiegato in svariati studi clinici,[3] alcuni dei quali hanno raggiunto la fase II.[4]

Nel dicembre 2015, tre studi clinici (SIRROUND-D, -H e -T) avevano raggiunto la fase III.[5] In particolare, nel febbraio 2017, lo studio SIRROUND-D risultava avere raggiunto entrambi gli obiettivi principali che erano stati prefissati in fase di pianificazione della sperimentazione clinica; lo studio, inoltre, dimostrò una diminuzione della gravità del quadro clinico nei pazienti con artrite reumatoide che avevano ricevuto il sirukumab.[6]

Precedentemente, era stato proposto l'utilizzo del sirukumab anche come trattamento della depressione maggiore.[7]

Note

  1. ^ (EN) Sirukumab (PDF), su American Medical Association. URL consultato il 2 aprile 2023.
  2. ^ (EN) Bartoli F, Bae S, Cometi L, Matucci Cerinic M, Furst DE, Sirukumab for the treatment of rheumatoid arthritis: update on sirukumab, 2018, in Expert Review of Clinical Immunology, vol. 14, n. 7, luglio 2018, pp. 539–547, DOI:10.1080/1744666X.2018.1487291, PMID 29925278.
  3. ^ a b (EN) Interleukin-6 Inhibitor Sirukumab (CNTO 136) Phase 2 Data Show Promise in the Treatment of Active Rheumatoid Arthritis, su PR News Wire, 25 maggio 2011. URL consultato il 2 aprile 2023.
  4. ^ (EN) A Study of the Effectiveness and Safety of CNTO 136 in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy, su ClinicalTrials.gov. URL consultato il 2 aprile 2023.
  5. ^ (EN) House DW, Glaxo says top-line results positive in late-stage study of sirukumab in rheumatoid arthritis, su Seeking Alpha, 16 dicembre 2015. URL consultato il 2 aprile 2023.
  6. ^ (EN) IL-6 in RA: What Predicts Non-Progression? - High-risk patients showed most benefit with sirukumab, su MedPageToday, gennaio 2017. URL consultato il 2 aprile 2023.
  7. ^ (EN) Sirukumab - Janssen Biotech, su Adis Insight. URL consultato il 2 aprile 2023.

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