Sertaconazolo

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Sertaconazolo
Struttura chimica del sertaconazolo
Struttura chimica del sertaconazolo
Caratteristiche generali
Formula bruta o molecolareC20H15Cl3N2OS
Massa molecolare (u)437.77 g/mol
Numero CAS99592-32-2
Codice ATCD01AC14
PubChem65863
DrugBankDBDB01153
SMILES
Clc1ccc (c(Cl)c1) C(OCc2c3cccc (Cl)c3sc2) Cn4ccnc4
Indicazioni di sicurezza

Il sertaconazolo è un farmaco antimicotico della famiglia dei derivati imidazolici[1].

Agisce bloccando la sintesi dell'ergosterolo nella cellula micotica inibendo l'enzima 14α-demetilasi[1].

Stereochimica

Il sertaconazolo contiene uno stereocentro e consiste di due enantiomeri. Si utilizza come racemo, cioè una miscela in rapporto 1:1 delle forme ( R ) e ( S ):[2]

Enantiomeri di sertaconazolo

CAS-Nummer: 583057-48-1

CAS-Nummer: 583057-51-6

Note

  1. ^ a b AJ. Carrillo-Muñoz, C. Tur-Tur; G. Giusiano; C. Marcos-Arias; E. Eraso; N. Jauregizar; G. Quindós, Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis., in Expert Rev Anti Infect Ther, vol. 11, n. 4, aprile 2013, pp. 347-58, DOI:10.1586/eri.13.17, PMID 23566144.
  2. ^ Rote Liste Service GmbH (Hrsg.): Rote Liste 2017 – Arzneimittelverzeichnis für Deutschland (einschließlich EU-Zulassungen und bestimmter Medizinprodukte). Rote Liste Service GmbH, Frankfurt/Main, 2017, Aufl. 57, ISBN 978-3-946057-10-9, S. 217.

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