Detoksifikasi

Untuk pengobatan berbasis ilmu semu, lihat Detoksifikasi (pengobatan alternatif).

Pada fisiologi, detoksifikasi atau pengawaracunan (bahasa Inggris: detoxification, detox) adalah lintasan metabolisme yang mengurangi kadar racun di dalam tubuh,[1] dengan penyerapan, distribusi, biotransformasi dan ekskresi molekul toksin.[2]

Peroksidase merupakan keluarga enzim detoksifikasi dengan fungsi katalisator reaksi reduksi H2O2 dengan kopling reduksi berbagai substrat lain.[3] Umumnya peroksidase mengandung heme yang menggunakan hidrogren peroksida untuk mempercepat reaksi oksidasi.

Detoksifikasi terbagi menjadi 3 klasifikasi menurut golongan substratnya yaitu alkohol, obat-obatan dan zat metabolik.

Referensi

  1. ^ (Inggris) "detoxification". Farlex free dictionary. Diakses tanggal 2010-10-18. 
  2. ^ (Inggris) "Toxicology Primer". University of Illinois at Chicago. Diakses tanggal 2010-10-18. 
  3. ^ (Inggris) "Engineering Ascorbate Peroxidase Activity into Cytochrome c Peroxidase". Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California; Yergalem T. Meharenna, Patricia Oertel, B. Bhaskar, dan Thomas L. Poulos. Diakses tanggal 2010-11-26. 


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