נוקאאוט גנטי

נוקאאוט גנטיאנגלית: Gene knockout או בקצרה .Gene K.O) היא שיטה גנטית להנדס יצור בו גן או קבוצת גנים מסוימת יוצאים מכלל שימוש (פירוש נוקאאוט באנגלית הוא הוצאה) ולמעשה מושתקים. בהשוואה ליצורים נורמלים, יצורי הנוק-אאוט משמשים למחקר לגבי תפקיד הגנים שהושתקו. השתקה יכולה להיות הטרוזיגוטית (של אלל אחד) או הומוזיגוטית (של שני האללים).

התהליך של החדרת גן חליפי במקום זה שהושתק נקרא נוקאין גנטי.

ישנן מספר דרכים לבצע נוקאאוט ונוקאין גנטי, ביניהן באמצעות קריספר[1] או באמצעות נוקלאזות[2] ספציפיות לאתר קריטי בתהליך שעתוק/תרגום הגן, כמו למשל באתר שחבור.

הערות שוליים

ערך זה הוא קצרמר בנושא ביולוגיה. אתם מוזמנים לתרום לוויקיפדיה ולהרחיב אותו.

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