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Linfotoxina beta
A linfotoxina beta (LT-beta) tamén chamada factor de necrose tumoral C (TNF-C) é unha proteína con funcións reguladoras inmunitarias, que nos humanos está codificada no xene LTB do cromosoma 6.[1][2][3]
Función
A linfotoxina beta é un tipo de proteína de membrana de tipo II da familia do factor de necrose tumoral. Funciona ancorando a linfotoxina alfa á superficie da célula por medio da formación dun heterotrímero. A forma predominante da superficie dos linfocitos é o complexo linfotoxina alfa 1/beta 2 (é dicir, 1 molécula alfa/2 moléculas beta) e este complexo é o ligando primario do receptor da linfotoxina beta. Un complexo menos frecuente é o linfotoxina alfa 2/beta 1. A linfotoxina beta é un indutor do sistema de resposta inflamatoria e está implicada no desenvolvemento normal do tecido linfoide. A isoforma b da linfotoxina beta non pode formar complexo coa linfotoxina alfa, o que suxire que hai unha función para a linfotoxina beta que é independente da linfotoxina alfa. O splicing alternativo dá lugar a moitas variantes de transcrición que codifican diferentres isoformas.[3]
Interaccións
A linfotoxina beta presenta interaccións coa linfotoxina alfa.[4][5][6]
Notas
- ↑ Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF (April 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell 72 (6): 847–56. PMID 7916655. doi:10.1016/0092-8674(93)90574-A.
- ↑ Browning JL, Androlewicz MJ, Ware CF (September 1991). "Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma". J Immunol 147 (4): 1230–7. PMID 1714477.
- ↑ 3,0 3,1 "Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)".
- ↑ Williams-Abbott, L; Walter B N; Cheung T C; Goh C R; Porter A G; Ware C F (August 1997). "The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand". J. Biol. Chem. (UNITED STATES) 272 (31): 19451–6. ISSN 0021-9258. PMID 9235946. doi:10.1074/jbc.272.31.19451.
- ↑ Browning, J L; Sizing I D, Lawton P, Bourdon P R, Rennert P D, Majeau G R, Ambrose C M, Hession C, Miatkowski K, Griffiths D A, Ngam-ek A, Meier W, Benjamin C D, Hochman P S (October 1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes". J. Immunol. (UNITED STATES) 159 (7): 3288–98. ISSN 0022-1767. PMID 9317127.
- ↑ Browning, J L; Dougas I; Ngam-ek A; Bourdon P R; Ehrenfels B N; Miatkowski K; Zafari M; Yampaglia A M; Lawton P; Meier W (January 1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors". J. Immunol. (UNITED STATES) 154 (1): 33–46. ISSN 0022-1767. PMID 7995952.
Véxase tamén
Outros artigos
Bibliografía
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