Suproclone

Identification
Suproclone

Suproclone
Nom UICPA	[6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7- dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl]-4-propanoylpipérazine-1-carboxylate
N^o CAS	77590-92-2
N^o ECHA	100.071.330
PubChem	53696
SMILES	O=C(N5CCN(C(=O)OC4C=1SCCSC=1C(=O)N4c2nc3nc(Cl)ccc3cc2)CC5)CC PubChem, vue 3D
InChI	InChI : vue 3D InChI=1/C22H22ClN5O4S2/c1-2-16(29)26-7-9-27(10-8-26)22(31)32-21-18-17(33-11-12-34-18)20(30)28(21)15-6-4-13-3-5-14(23)24-19(13)25-15/h3-6,21H,2,7-12H2,1H3 InChIKey : IBAUKGNDWVSETP-UHFFFAOYAD Std. InChI : vue 3D InChI=1S/C22H22ClN5O4S2/c1-2-16(29)26-7-9-27(10-8-26)22(31)32-21-18-17(33-11-12-34-18)20(30)28(21)15-6-4-13-3-5-14(23)24-19(13)25-15/h3-6,21H,2,7-12H2,1H3 Std. InChIKey : IBAUKGNDWVSETP-UHFFFAOYSA-N
Propriétés chimiques
Formule	C₂₂H₂₂Cl N₅O₄S₂ [Isomères]
Masse molaire^[1]	520,024 ± 0,033 g/mol C 50,81 %, H 4,26 %, Cl 6,82 %, N 13,47 %, O 12,31 %, S 12,33 %,

Unités du SI et CNTP, sauf indication contraire.
modifier

Le suproclone est un médicament sédatif et anxiolytique de la famille des cyclopyrrolones (en), développé par la société pharmaceutique française Rhône-Poulenc^[2].

Structure et mode d'action

La famille des cyclopyrrolones comprend le zopiclone, le pagoclone (en) et le suriclone (en).

Le suproclone possède une structure très similaire à celle du suriclone, mais peu d'informations ont été publiées à ce sujet en particulier. Toutefois, il peut être supposé que le mécanisme d'action par lequel le suproclone produit ses effets sédatifs et anxiolytiques passe par une action sur les récepteurs des benzodiazépines^[3]^,^[4].

Notes et références

↑ Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur www.chem.qmul.ac.uk.
↑ Psychotropics.dk, « suproclone »
↑ Colin R. Gardner. Pharmacological profiles in vivo of benzodiazepine receptor ligands. Drug Development Research 1988. 12(1):1-28.
↑ Ian L. Martin, Adam Doble, David J. Nutt. Calming the Brain: Benzodiazepines and Related Drugs from Laboratory to Clinic. Informa Healthcare (24 octobre 2003). (ISBN 1-84184-052-1)

Voir aussi

Articles connexes

v · m

Psycholeptiques : hypnotiques et sédatifs (N05C)

Récepteurs GABA_A

Barbiturique	action ultra-courte : Méthohexital Thiamylal Thiopental action courte et intermédiaire : Allobarbital Amobarbital Butabarbital Butobarbital Pentobarbital Sécobarbital Talbutal action longue : Barbital Méphobarbital Phénobarbital non regroupés : Cyclobarbital Éthallobarbital Heptabarbital Hexobarbital Proxibarbal Reposal Vinylbital Vinbarbital
Benzodiazépines	action courte : Brotizolam Cinolazépam Doxefazépam Loprazolam Midazolam Triazolam action intermédiaire : Estazolam Flunitrazépam Lormétazépam Nimetazépam Témazépam action longue : Flurazépam Flutoprazépam Nitrazépam Quazepam
Dialkylphénols	Fospropofol Propofol Thymol
Non-benzodiazépines	CL-218,872 Eszopiclone Indiplon Lirequinil Nécopidem Pazinaclone ROD-188 Saripidem Suproclone Suriclone SX-3228 U-89843A U-90042 Zaleplon Zolpidem Zopiclone
Pipéridinediones	Glutéthimide Méthyprylon Pyrithyldione Pipéridione
Quinazolinones	Afloqualone Cloroqualone Diproqualone Étaqualone Mébroqualone Mécloqualone Méthaqualone Méthylmethaqualone Nitrométhaqualone
Stéroïde neuroactif	Acébrochol Alloprégnanolone Alfadolone Alphaxolone Eltanolone Ganaxolone Hydroxydione Minaxolone Org 20599 Org 21465 Tétrahydrodéoxycorticostérone

Récepteurs adrénergiques alpha-2

Agoniste alpha-adrénergique	4-NEMD Clonidine Dexmédétomidine Lofexidine Médétomidine Romifidine Tizanidine Xylazine

Récepteur de mélatonine

Mélatonine	Agomélatine Mélatonine Rameltéon Tasimeltéon

Récepteur d'histamine et récepteur d'acétylcholine

Antihistaminiques et anticholinergiques	Doxylamine Hydroxyzine Diphénhydramine Bromodiphénhydramine Carbinoxamine Orphénadrine Niaprazine Phényltoloxamine Propiomazine Pyrilamine Scopolamine

Récepteur GABA_B et récepteurs GHB

Type GHB	1,4-butanediol Acide acéburique GABOB GHB (Oxybate de sodium) GBL Gamma-valérolactone N-méthyl-GABA

Autres récepteurs

Aldéhydes	Hydrate d'acétylglycinamide chloral Hydrate de chloral Chloralodol Dichloralphénazone Paraldéhyde Pétrichloral
Alcynes	Centalun Ethchlorvynol Éthinamate Hexapropymate Méthylpentynol
Carbamates	Méprobamate Carisoprodol Tybamate Méthocarbamol
Autre	2-méthyl-2-butanol Acécarbromal Apronal Bromures Bromisoval Carbromal Chloralose Clométhiazole Embutramide Étomidate Évoxine Gaboxadol Loréclézole Mephenoxalone Sulfoneméthane Trichloroéthanol Triclofos Valériane Valnoctamide Trazodone

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