Furine

Furine
Description de cette image, également commentée ci-après
Structure d'une furine de souris (PDB 1P8J[1])
N° EC EC 3.4.21.75
N° CAS 141760-45-4
Activité enzymatique
IUBMB Entrée IUBMB
IntEnz Vue IntEnz
BRENDA Entrée BRENDA
KEGG Entrée KEGG
MetaCyc Voie métabolique
PRIAM Profil
PDB RCSB PDB PDBe PDBj PDBsum
GO AmiGO / EGO

modifier

La furine est une protéase à sérine qui catalyse le clivage d'un polypeptide au niveau typiquement d'une séquence basique de la forme –Arg–Xaa–(Arg/Lys)–Arg-|- où Xaa représente un résidu d'acide α-aminé protéinogène quelconque.

Cette enzyme, à l'action très spécifique, libère notamment l'albumine, le composant 3 du système du complément et le facteur de von Willebrand par clivage de leur précurseur respectif. Elle participe également au clivage du peptide C de l'insuline (comprenant des séquences basiques) en rendant cette dernière sous sa forme active (liaison des chaines A et B via ponts disulfures). Elle intervient donc pour finaliser la synthèse de certaines protéines en leur conférant leur structure fonctionnelle[2],[3],[4],[5].

Notes et références

  1. ↑ (en) Stefan Henrich, Angus Cameron, Gleb P. Bourenkov, Reiner Kiefersauer, Robert Huber, Iris Lindberg, Wolfram Bode et Manuel E. Than, « The crystal structure of the proprotein processing proteinase furin explains its stringent specificity », Nature Structural Biology, vol. 10, no 7,‎ , p. 520-526 (PMID 12794637, DOI 10.1038/nsb941, lire en ligne)
  2. ↑ (en) Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ, « Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site », Proc Natl Acad Sci U S A, vol. 87, no 23,‎ , p. 9378–82 (PMID 2251280, PMCID 55168, DOI 10.1073/pnas.87.23.9378)
  3. ↑ (en) Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ, « Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15 », DNA Cell Biol, vol. 10, no 10,‎ , p. 757–69 (PMID 1741956, DOI 10.1089/dna.1991.10.757)
  4. ↑ (en) « Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme) »
  5. ↑ (en) Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP, Van de Ven WJ, « Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein », EMBO J., vol. 5, no 9,‎ , p. 2197–202 (PMID 3023061, PMCID 1167100)

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