Fluvoksamiini

Fluvoksamiini
Systemaattinen (IUPAC) nimi
?
Tunnisteet
CAS-numero 54739-18-3
ATC-koodi N06AB08
PubChem CID 5324346
DrugBank DB00176
Kemialliset tiedot
Kaava C15H21N2F3O2 
Moolimassa 318,34 g/mol
Farmakokineettiset tiedot
Hyötyosuus 53 % [1]
Proteiinisitoutuminen 80 % [1]
Metabolia maksa [1]
Puoliintumisaika 13–15 h [1]
Ekskreetio ?
Terapeuttiset näkökohdat
Raskauskategoria

?

Reseptiluokitus

reseptivalmiste (FI)

Antotapa suun kautta

Fluvoksamiini (Suomessa valmistenimellä Fluvosol[2]) on SSRI-lääkkeiden eli selektiivisten serotoniinin takaisinoton estäjien ryhmään kuuluva lääkeaine. Sitä käytetään vakavan masennuksen ja pakko-oireisen häiriön hoitoon.[3]

Käyttö ja vaikutukset

Fluvoksamiinin vaikutuksen alkaminen vie noin kaksi viikkoa, joskus kauemmin. Aikuisille tavallinen aloitusannos on 50–100 milligrammaa vuorokaudessa ja enimmäisannos 300 milligrammaa vuorokaudessa.[4] Fluvoksamiinin määritelty vuorokausiannos (DDD-yksikkönä) suhteessa väestöön on 100 mg.[5]

Sivuvaikutukset

Lääkkeen yleisimpiin haittavaikutuksiin kuuluvat sydämentykytys, päänsärky, huimaus, uneliaisuus, vapina, vatsavaivat, suun kuivuminen, hikoilu, ruokahaluttomuus, voimattomuus, huonovointisuus, ahdistuneisuus, unettomuus ja hermostuneisuus.[3]

Vieroitusoireet

Lopetettaessa fluvoksamiinin käyttö, yleisimmät lopetusoireet ovat lääkkeen sivuvaikutusten kaltaisia. Yleisimpiä oireita ovat muun muassa huimaus, aisti- ja unihäiriöt, kiihtymys, sydämentykytykset ja päänsärky. Vieroitusoireiden välttämiseksi lääkeannosta kannattaa pienentää vähitellen.[4]

Covid-tutkimus

Fluvoksamiinia on myös tutkittu Covid-19-tartunnan hoidossa.[6][7] [8] Toukokuussa 2022 Yhdysvaltain elintarvike- ja lääkevirasto (FDA) hylkäsi poikkeusmyyntiluvan fluvoksamiinilta covid-19-sairauden hoitoon katsoen ettei näyttö ollut annetuissa tutkimuksissa riittävä luvan myöntämiseen.[9][10] Myös Maailman terveysjärjestö ilmaisi heinäkuussa 2022 että ei suosita lääkkeen käyttöä covid-19-sairauden hoitoon.[11]

Lähteet

  1. ↑ a b c d CPMP summary information on referral opinion following arbitration pursuant to article 30 of Council directive 2001/83/EC for Floxyfral and associated names, INN-fluvoxamine ema.europa.eu. Viitattu 10.11.2018.
  2. ↑ Ihmisille tarkoitettujen lääkevalmisteiden valmisteyhteenvedot ATC-koodin perusteella: N06AB08 Fimea. Viitattu 16.2.2024.
  3. ↑ a b Lääkeinfo.fi - lääkevalmisteiden pakkausselosteet - FLUVOSOL tabletti, kalvopäällysteinen 100 mg laakeinfo.fi. Viitattu 17.7.2022.
  4. ↑ a b Pakkausseloste, Fluvosol spc.fimea.fi. Arkistoitu 11.11.2018. Viitattu 10.11.2018.
  5. ↑ ATC/DDD-index atcddd.fhi.no. Viitattu 29.11.2024. (englanniksi)
  6. ↑ What’s the Evidence for Fluvoxamine in COVID-19? The Scientist Magazine®. Viitattu 17.7.2022. (englanniksi)
  7. ↑ William A. Haseltine: Six Ways Fluvoxamine May Act To Prevent Severe Covid-19 Forbes. Viitattu 17.7.2022. (englanniksi)
  8. ↑ William A. Haseltine: New Analysis Shows Fluvoxamine Has The Potential To Reduce Covid-19 Hospitalizations By More Than 90% Forbes. Viitattu 17.7.2022. (englanniksi)
  9. ↑ FDA rejects antidepressant seen as possible Covid-19 treatment STAT. 16.5.2022. Viitattu 17.7.2022. (englanti)
  10. ↑ Kelsey Piper: Why the FDA rejected fluvoxamine as a Covid-19 drug Vox. 20.5.2022. Viitattu 17.7.2022. (englanniksi)
  11. ↑ WHO advises against fluvoxamine, colchicine for COVID-19 UPI. Viitattu 17.7.2022. (englanniksi)
Antidepressantit
Valikoivat takaisinoton estäjät ja/tai reseptorimodulaattorit
SNRI:t
NRI:t
SARI:t
SMS:t
Muut
Tetrasykliset masennuslääkkeet
Ei-selektiiviset
MAOA-selektiiviset
MAOB-selektiiviset
selegiliini

‡ markkinoilta poistettu lääke, † kokeellinen lääke,* ei myynnissä Suomessa

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