Nav1.3
Nav1.3 که با نامِ کانال سدیم، با درگاه وابستهبه ولتاژ، نوع ۳، زیرواحد آلفا (انگلیسی: Sodium channel, voltage-gated, type I, alpha subunit) هم شناخته میشود، یک پروتئین است که در انسان توسط ژن «SCN3A» کُدگذاری میشود.[۴]
این کانال در ایجاد و هدایت پتانسیل عمل در اعصاب و ماهیچهها نقش دارد.
این مجرا، تنها کانال سدیمی است که که به دنبال آسیب عصبی تغییر میکند.
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000057182 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: SCN3A sodium channel, voltage-gated, type III, alpha subunit".
- مشارکتکنندگان ویکیپدیا. «SCN3A». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۸ ژوئن ۲۰۱۸.
بیشتر بخوانید
- Catterall WA, Goldin AL, Waxman SG (2006). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.
- Malo MS, Srivastava K, Andresen JM, et al. (1994). "Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 2975–9. doi:10.1073/pnas.91.8.2975. PMC 43497. PMID 8159690.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Lu CM, Brown GB (1998). "Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit". J. Mol. Neurosci. 10 (1): 67–70. doi:10.1007/BF02737087. PMID 9589372.
- Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
- Chen YH, Dale TJ, Romanos MA, et al. (2001). "Cloning, distribution and functional analysis of the type III sodium channel from human brain". Eur. J. Neurosci. 12 (12): 4281–9. doi:10.1046/j.1460-9568.2000.01336.x. PMID 11122339.
- Kasai N, Fukushima K, Ueki Y, et al. (2001). "Genomic structures of SCN2A and SCN3A – candidate genes for deafness at the DFNA16 locus". Gene. 264 (1): 113–22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985.
- Whitaker WR, Faull RL, Dragunow M, et al. (2001). "Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus". Neuroscience. 106 (2): 275–85. doi:10.1016/S0306-4522(01)00212-3. PMID 11566500.
- Weiss LA, Escayg A, Kearney JA, et al. (2003). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Mol. Psychiatry. 8 (2): 186–94. doi:10.1038/sj.mp.4001241. PMID 12610651.
- Shah BS, Rush AM, Liu S, et al. (2004). "Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface". J. Neurosci. 24 (33): 7387–99. doi:10.1523/JNEUROSCI.0322-04.2004. PMID 15317864.
- Thimmapaya R, Neelands T, Niforatos W, et al. (2005). "Distribution and functional characterization of human Nav1.3 splice variants". Eur. J. Neurosci. 22 (1): 1–9. doi:10.1111/j.1460-9568.2005.04155.x. PMID 16029190.
- Platoshyn O, Remillard CV, Fantozzi I, et al. (2006). "Identification of Functional Voltage-gated Na+ Channels in Cultured Human Pulmonary Artery Smooth Muscle Cells". Pflugers Arch. 451 (2): 380–7. doi:10.1007/s00424-005-1478-3. PMC 1351366. PMID 16052353.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Martin MS, Tang B, Ta N, Escayg A (2007). "Characterization of 5′ untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences". Genomics. 90 (2): 225–35. doi:10.1016/j.ygeno.2007.04.006. PMC 2637551. PMID 17544618.
پیوند به بیرون
- SCN3A protein, human در سرعنوانهای موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
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