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Glibenklamida

Glibenklamida
Formula kimikoaC23H28ClN3O5S
SMILES kanonikoa2D eredua
SMILES isomerikoa
COC1=CC=C(C=C1/C(=N\CCC2=CC=C(C=C2)S(=O)(=O)N/C(=N\C3CCCCC3)/O)/O)Cl
MolView3D eredua
Motasulfonylurea (en) Itzuli
Ezaugarriak
Fusio-puntua173 ℃
Masa molekularra493,144 Da
Erabilera
Konposatu aktiboaDiabeta (en) Itzuli eta Glynase (en) Itzuli
Tratatzen dumaturity-onset diabetes of the young type 2 (en) Itzuli
Interakzioakbosentan hydrate (en) Itzuli, bosentan hydrate (en) Itzuli, Klaritromizina eta Sulfametoxazol
ElkarrekintzaCFTR, Potassium voltage-gated channel subfamily J member 8 (en) Itzuli, Potassium inwardly rectifying channel, subfamily J, member 11 (en) Itzuli, Potassium inwardly rectifying channel subfamily J member 11 (en) Itzuli eta Solute carrier organic anion transporter family member 2B1 (en) Itzuli
HaurdunaldiaAustralian pregnancy category C (en) Itzuli eta US pregnancy category B (en) Itzuli
Roladiabetes-kontrako eta WHO farmako esentzial
Identifikatzaileak
InChlKeyZNNLBTZKUZBEKO-UHFFFAOYSA-N
CAS zenbakia10238-21-8
ChemSpider3368
PubChem3488
Reaxys2230085
Gmelin5441
ChEMBLCHEMBL472
RTECS zenbakiaYS4725200
ZVG36640
DSSTox zenbakiaYS4725200
EC zenbakia233-570-6
ECHA100.030.505
MeSHD005905
RxNorm4815
Human Metabolome DatabaseHMDB0015151
UNIISX6K58TVWC
NDF-RTN0000146417
KEGGC07022 eta D00336
PDB LigandGBM
Ohar medikoa
Ohar medikoa
Oharra: Wikipediak ez du mediku aholkurik ematen. Tratamendua behar duzula uste baduzu, jo ezazu sendagilearengana.

Glibenklamida, gliburida izenez ere ezaguna, sulfonilureen klaseko aho bidezko sendagai hipogluzemiatzailea da, diabetes mellitus ez intsulina-mendekoaren tratamenduan erabiltzen dutena. Diabetes mellitus intsulina-mendekorako, berriz, ez da gomendagarria.

Glibenklamida 1969an patentatu eta 1984an merkaturatu zuten.[1]

Erreferentziak

  1. ↑ (Ingelesez) Fischer, Janos; Ganellin, C. Robin. (2006). Analogue-based Drug Discovery. John Wiley & Sons, 489 or. ISBN 9783527607495..

Kanpo estekak


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