Ácido fusídico

estructura ácido 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetiloxi)-5,17-dihidroxi-2,6,10,11- tetrametiltetraciclo[8.7.0.02,7.011,15] heptadecan-14-iliden]-6-metilhept-5-enoic

El ácido fusídico es un agente bacteriostático que a menudo se emplea tópicamente en cremas y gotas oftalmológicas, que también se puede emplear en comprimidos o inyectables.[1]​

Farmacología

El ácido fusídico es un inhibidor de la síntesis proteíca bacteriana que evita el turnover del factor de elongación G del ribosoma. El ácido fusídico sólo es efectivo contra bacterias gram-positivas incluyendo especies de Staphylococcus y Corynebacterium . El ácido fusídico inhibe la replicación bacteriana y no es bactericida, es decir sólo es un "bacteriostático".

Interacciones

El ácido fusídico no debe emplearse con quinolonas, ya que las antagoniza. Aunque durante décadas el ácido fusídico ha sido extensamente utilizado en la práctica clínica asociado con rifampicina, recientemente un ensayo clínico demostró que existe una interacción de tipo antagónico en dicha combinación de antibióticos.[2]​

Se había informado el 8 de agosto de 2008, que el Irish Medicines Board estaba investigando el deceso de un irlandés varón de 59 años que había desarrollado rabdomiólisis después de tomarlo asociado a atorvastatina, y otros tres casos similares.[3]​

En el mercado están disponibles las formas ungüento, crema, gota oftalmológicas y en tabletas.

Referencias

  1. ↑ Falagas ME, Grammatikos AP, Michalopoulos A. Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther. 2008; 6(5):593-600 PMID 18847400
  2. ↑ «Pushkin R, Iglesias-Ussel MD, MacLauchlin C, Mould DD, Berkowitz R, Kreuzer S, et al. A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug–Drug Interaction». Clinical Infectious Diseases 63 (12): 1599-1604. 2016. doi:10.1093/cid/ciw665. 
  3. ↑ http://www.independent.ie/national-news/man-died-after-rare-medical-reaction-to-cholesterol-drug-1449275.html


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