Glucosa-6-fosfato deshidrogenasa (coenzima-F420)

Estructuras disponibles

Estructuras enzimáticas

Identificadores

Identificadores
externos

Bases de datos de enzimas

IntEnz: entrada en IntEnz
BRENDA: entrada en BRENDA
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica

Número EC

1.1.98.2

Ortólogos

Especies

Humano

Ratón

PubMed (Búsqueda)

[1]

PMC (Búsqueda)

[2]

[editar datos en Wikidata]

La Glucosa-6-fosfato deshidrogenasa (coenzima-F420) (EC 1.1.98.2, es una enzima que cataliza la siguiente reacción química:

D-glucosa 6-fosfato + coenzima F420_(oxidada)

\rightleftharpoons

6-fosfo-D-glucono-1,5-lactona + coenzima F420_(reducida)

Por lo tanto los dos sustratos de esta enzima son D-glucosa 6-fosfato y coenzima F420 oxidada; mientras que los dos productos son 6-fosfo-D-glucono-1,5-lactona y coenzima F420 reducida.

Clasificación

Esta enzima pertenece a la familia de las oxidorreductasas, más específicamente a aquellas oxidorreductasas que actúan sobre grupos CH-OH utilizándolos como dadores de electrones y con otros aceptores conocidos.

Nomenclatura

El nombre sistemático de esta enzima es D-glucosa-6-fosfato:F420 1-oxidoreductasa. Otros nombres con los que se la conoce pueden ser: glucosa-6-fosfato deshidrogenasa coenzima F420-dependiente, glucosa-6-fosfato deshidrogenasa F420-dependiente, FGD1, Rv0407 y glucosa-6-fosfato deshidrogenasa 1 F420-dependiente.

Estructura y características

Originalmente descubierta en Mycobacterium smegmatis, se pudo determinar que esta enzima no podía utilizar NAD, ni NADP como cofactor. Una vez purificada, reveló una estructura homodimérica con una masa de 78 KDa. Un estudio posterior que analizó una serie de organismos de los que se sabía contienen la coenzima F420, encontró que todas las especies de crecimiento libre de Mycobacterium, incluyendo la especie patógena Mycobacterium tuberculosis poseen esta actividad.^[1] La enzima posee una altísima especificidad para la glucosa-6-fosfato.

El gen fgd1 de Mycobacterium tuberculosis que codifica para esta enzima ha sido clonado y sobreexpresado en Mycobacterium smegmatis como una proteína de fusión marcada con histidina. Esta proteína recombinante ha sido purificada y su estructura ha sido determinada por cristalografía de rayos X a una resolución de 2.1 Ångstrom.^[1]^[2]^[3]

Referencias

↑ ^a ^b Purwantini, E. and Daniels, L. (1996). «Purification of a novel coenzyme F₄₂₀-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis». J. Bacteriol. 178 (10): 2861-2866. PMC 178021. PMID 8631674.
↑ Bashiri, G., Squire, C.J., Baker, E.N. and Moreland, N.J. (2007). «Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system». Protein Expr. Purif. 54 (1): 38-44. PMID 17376702. doi:10.1016/j.pep.2007.01.014.
↑ Purwantini, E., Gillis, T.P. and Daniels, L. (1997). «Presence of F₄₂₀-dependent glucose-6-phosphate dehydrogenase in Mycobacterium and Nocardia species, but absence from Streptomyces and Corynebacterium species and methanogenic Archaea». FEMS Microbiol. Lett. 146 (1): 129-134. PMID 8997717. doi:10.1111/j.1574-6968.1997.tb10182.x.

Enlaces externos

MeSH: Glucose-6-phosphate+dehydrogenase+(coenzyme-F420) (en inglés)

Datos: Q2791741

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