Diaminopirimidina

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Las diaminopirimidinas son fármacos que inhiben la síntesis de folato en la bacteria mediante la interacción con la enzima dihidrofolato-reductasa (encargada de pasar de folato a ácido tetrahidrofólico para poder sintetizar bases del ADN). Son de absorción oral muy rápida y muy hidrosolubles. Su distribución en el organismo es muy amplia (llegan al feto) y se quedan unidas a los tejidos. Su metabolismo es hepático y su eliminación, renal (un 80% sin eliminar). Se usan normalmente como potenciadoras de las sulfamidas unidas a ellas en una relación 5:1. Así se obtienen las sulfamidas potenciadas (pocos efectos tóxicos y de amplio espectro).

Ejemplos de diaminopirimidinas usados en veterinaria y en humanos es la Trimetoprima que se vende en comprimidos y suspensiones junto con el antibiótico sulfametoxazol, otro es la Pirimetamina.

Datos: Q409994

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