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Victor Despeignes
Victor Despeignes
Born	14 February 1866; Lyons, France
Died	30 July 1937 (aged 71)
Nationality	French
Known for	First to use radiation therapy to treat cancer

Victor Despeignes (14 February 1866 – 30 July 1937 )^[1]^[2] was a pioneer in radiation oncology. He was possibly the first person to use X-rays to treat cancer, which he did in July 1896 for a patient with stomach cancer.^[1]^[3] He was also the first physician to publish a paper on radiation therapy, in 1896, dealing with that case.^[4]^[5] This attempt was less than a year after the publication of the discovery of X-rays by Wilhelm Röntgen.^[6]

Personal life

François Victor Despeignes was born in Lyon in 1866.^[3] He was buried at the cemetery in a small village in the Drôme Provençale called Vinsobres.

Cancer treatment

Researchers had already discovered that X-rays could kill bacteria by 1896. The predominant theory at the time was that cancer was some kind of parasitic infection. Louis Charles Émile Lortet and Philibert Jean Victor Genoud tried to kill tuberculosis in infected guinea pigs using X-rays from March to June 1896 in the same city of Lyon.^[7]^[3]

A 52-year-old man with an epigastric tumor presented to Despeignes.^[8]^[9] The tumor was about the size of the head of an eight-month-old fetus. Despeignes believed that cancer was caused by parasites, and that perhaps he could kill the parasite with radiation.^[3] On 4 July 1896 he commenced the X-ray treatments. Two half-hour treatments were given each day. Other treatments given to the patient were opium for pain relief, morphine and chloroform. A diet of condurango and milk was prescribed, with injections of artificial serum. The patient experienced pain relief, but died on 24 July.^[10] The cancer had shrunk by about 50%.^[3] Despeignes' equipment consisted of a Crookes' tube and six Radiguet battery elements.^[3]

Inspired by this, other physicians tried using X-rays to treat numerous human ailments from acne to breast cancer.^[11] Malignancies were found to be the most amenable to X-ray treatment. They also found out the side effects.^[3]

Other work

Between 1866 and 1894, Despeignes worked as a hygienist physician in Lyon. He researched the quality of tap water and tuberculosis. He became the chief of the laboratory of Louis Pasteur in 1892.^[3] Between 1907 and 1937 he was the director of town hygiene in Chambéry.^[12]

Works

"Nouveau régulateur pour étuve chauffée au pétrole" (New regulator for oven heated oil) Association Typographique, 1890
"A propos de la question des eaux de Lyon" (Concerning Lyon's waters) Association Typographique, Lyon, 1891
Despeignes, Victor (1891). Étude expérimentale sur les microbes des eaux, avec applications a l'hygiène sanitaire de la ville de Lyon. Paris: J.-B. Baillière.
"Deux cas de kyste hydatique" (Τwo cases of hydatid cysts) 1903 with Ph. Genoud^[3]

References

^ ^a ^b Wagener, D. J. Th. (2009). The History of Oncology. Bohn Stafleu van Loghum. p. 128. ISBN 978-9031361434.
^ "Les origines lyonnaises de la radiothérapie anticancéreuse". Et si on en parlait (in French). Université de Lyon. Retrieved 2016-11-05.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Sgantzos, M; Tsoucalas, G; Laios, K; Androutsos, G (2014). "The physician who first applied radiotherapy, Victor Despeignes, on 1896" (PDF). Hellenic Journal of Nuclear Medicine. 17 (1): 45–6. PMID 24563880.
^ Webb, S. (2001). Intensity-Modulated Radiation Therapy. CRC Press. p. 353. ISBN 978-1-4200-3411-0.
^ Lemoigne, Yves; Caner, Alessandra, eds. (2011). Radiation Protection in Medical Physics. Springer. p. 24. ISBN 978-9400702479.
^ Foray, Nicolas (November 2016). "Victor Despeignes, the Forgotten Pioneer of Radiation Oncology". International Journal of Radiation Oncology, Biology, Physics. 96 (4): 717–721. doi:10.1016/j.ijrobp.2016.07.019. PMID 27788944.
^ Lortet, Louid; Genoud, Philibert (1896). "Attenuation d'une tuberculose experimentale par la radiation Röntgen". Lyon Médical: Gazette Médicale et Journal de Médecine Réunis (in French). Retrieved 2016-11-06.
^ Despeignes, Victor (28 July 1896). "Observation concernant un cas de cancer de l'estomac traité par les rayons Röntgen". Lyon Médical: Gazette Médicale et Journal de Médecine Réunis (in French): 428–430. Retrieved 2016-11-06.
^ Foveau de Courmelles, François-Victor (1897). Traité de radiographie médicale et scientifique: cours libre professé à l'Ecole pratique de la Faculté de médecine de Paris, deuxième semestre de 1896–1897 (in French). pp. 429–430.
^ Despeignes, Victor (9 August 1896). "Observation concernant un cas de cancer de l'estomac traité par les rayons Röntgen". Lyon Médical: Gazette Médicale et Journal de Médecine Réunis (in French): 503–506. Retrieved 2016-11-06.
^ Despeignes, Victor (20 December 1896). "Nouvelle observation concernant un cas de cancer traité par les rayons Röntgen". Lyon Médical: Gazette Médicale et Journal de Médecine Réunis (in French): 503–506. Retrieved 2016-11-06. Parmi nos correspondants, l'un d'eux, M. le docteur L. Voigt, directeur de l'Institut vaccinal de la ville de Hambourg, a bien voulu nous communiquer les résultats qu'il a obtenus.
^ Foray, N. (June 2013). "Victor Despeignes (1866–1937): comment un hygiéniste devint le premier radiothérapeute de l'Histoire". Cancer/Radiothérapie. 17 (3): 244–254. doi:10.1016/j.canrad.2013.01.012. PMID 23522857.