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Urofollitropin
Clinical data
Trade names	Bravelle, Fertinex
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Subcutaneous, intramuscular
ATC code	G03GA04 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	97048-13-0 ;
PubChem CID	62819;
IUPHAR/BPS	1157;
DrugBank	DB00094 ;
ChemSpider	none;
UNII	W9BB98U6HP;
KEGG	D06400 ;
ChEMBL	ChEMBL1201520 ;
ECHA InfoCard	100.212.030
Chemical and physical data
Formula	C975H1513N267O304S26
Molar mass	22672.95 g·mol−1
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Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified^[1] to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility.^[2] It is also used with in vitro fertilization methods. The dosage is adjusted to each individual's response.^[2]

The most common side effects are abdominal or pelvic pain, bloating, as well as redness, pain or swelling at the injection site. Follitropin is possibly associated with increased risk of endometrial carcinoma. It is not for use during pregnancy, as there is evidence for birth defects under follitropin treatment.^[2]

Bravelle sold in the United States from March 2014 through October 2015 is subject to a recall and refund by its maker, Ferring Pharmaceuticals, because certain batches of the medicine had a lower strength than stated.^[3]