Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase

trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase
Identifiers
EC no.4.1.2.45
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase (EC 4.1.2.45, 2′-hydroxybenzalpyruvate aldolase, NsaE, tHBPA hydratase-aldolase) is an enzyme with systematic name (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O salicylaldehyde + pyruvate

This enzyme is involved in naphthalene degradation.

References

  1. ^ Kuhm AE, Knackmuss HJ, Stolz A (May 1993). "Purification and properties of 2'-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates". The Journal of Biological Chemistry. 268 (13): 9484–9. PMID 8486638.
  2. ^ Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J (July 2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology. 152 (Pt 7): 1929–40. doi:10.1099/mic.0.28783-0. PMID 16804169.
  3. ^ Eaton RW (December 1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". Journal of Bacteriology. 176 (24): 7757–62. doi:10.1128/jb.176.24.7757-7762.1994. PMC 197239. PMID 8002605.
  4. ^ Eaton RW (June 2000). "trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst". Applied and Environmental Microbiology. 66 (6): 2668–72. doi:10.1128/aem.66.6.2668-2672.2000. PMC 110598. PMID 10831455.