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Tissa may refer to:

• Devanampiya Tissa of Anuradhapura, King of Anuradhapura
• Prince Tissa, Sinhalese regent of the Kingdom of Tambapanni (454 BC–437 BC)
• Vitashoka, the brother of Ashoka, called Tissa in the Southern Buddhist tradition
• Tissa (prince), viceroy of Vientiane, took part in Lao rebellion (1826–1828)
• Tissa Balasuriya (1924–2013), Sri Lankan Roman Catholic priest and theologian
• Tissa Wijeyeratne (1923–2002), former Sri Lankan barrister, diplomat and businessman
• Tissa Vitharana (born 1934), Sri Lankan academic and politician

• Tissa, Germany, municipality in Thuringia, Germany
• Tissa, Cameroon, settlement of the Bata people
• Tisza, tributary of the Danube
• Tissa, India, village in the Muzaffarnagar district of Uttar Pradesh, and one of the twelve villages comprising the Saadat-e-Bara
• Tissa, Morocco

• Upatissa (disambiguation)
• Hermits Tissa and Thiha, Burmese Buddhist monks

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