Vu began her journalism career in public radio at KQED-FM in San Francisco and National Public Radio where she first covered Congress and national politics in Washington, D.C. before returning to their San Francisco bureau. Vu was at KPIX for four years as a reporter and fill-in anchor in the 1990s. She also reported at KTVU. Vu joined ABC7 News in August 2000 as co-anchor of the ABC7 Sunday Morning News at 7 a.m. and 9 a.m. She's also a reporter based in the South Bay Bureau. She joined CBS in December 2005, working out of the San Jose bureau, and remained with CBS in various capacities until 2012. She was an Emmy award-winning news anchor and reporter for CBS-5 "Eyewitness News" in San Francisco. She co-hosted the final year of KPIX's "Eye on the Bay" until original production ceased in May 2012.[5] Since September 2012, Vu has been a Multimedia Communications Instructor at Academy of Art University in San Francisco and a board member of the Asian Pacific Fund.[6] In 2013, she was the host of Link TV's LinkAsia news program, which is also broadcast on PBS.[7] She hosted the program until August 2014. Also in 2013, she began as host of the program KQED Newsroom on KQED-TV in San Francisco.[8] She hosted the program until June 2019.[9]