Historically, Thomas Bredsdorff researched literature from the 13th through 20th centuries, but mainly focused on 18th-century literature, on which he wrote a thesis (Digternes natur, 1976) and which he later published as the dissertation Den brogede oplysning (2004).
He has been a guest lecturer and visiting professor at many universities abroad, including the University of California, Berkeley in 2005.