The Powerpuff Girls: Chemical X-Traction is a 3D fighting game which the player controls one of the Powerpuff Girls (Blossom, Bubbles and Buttercup) who must battle enemies in a variety of settings in order to reclaim Chemical X and track down Mojo Jojo. The player can choose from ten playable characters which consist The Powerpuff Girls and seven villains.
The game had two modes - story mode, the players can pick up objects and throw them at an enemy to decrease their opponents health meter and use super powered attacks by collecting vials of Chemical X, and simulator mode, the player controls a Powerpuff Girl against a villain or a villain against another villain.
Plot
The Powerpuff Girls were making a delicious pie while Bubbles decided to add in Chemical X as an ingredient for the pie. Once they baked the pie, Mojo Jojo took the pie and shared it with his allies including Fuzzy Lumpkins, Big Billy, Ace, Sedusa and Princess Morbucks. The Powerpuff Girls eventually defeat Mojo Jojo but were surprised by HIM's sudden arrival so the fiend can use the Chemical X for himself. The girls defeated HIM and put the Chemical X back where it belongs.