The Mayor needs rescuing from Monster Island; meanwhile, Blossom and Buttercup fight over who gets to attend a concert with Bubbles.

When Buttercup starts hanging with the Derbytantes, Princess Morbucks wishes to join the Powerpuff Girls. Unfortunately, Princess betrays the girls by giving them a chest that lets out an indestructible "necronium" diamond heart that traps them inside, and it's up to Buttercup and the Derbytantes to save them and stop Princess Morbucks.

Recovering from a candy hangover that happened the night before, Blossom and Buttercup must retrace their steps to locate Bubbles, who is missing.

A mystical rainbow causes Townsville to become unnaturally happy, so the Powerpuff Girls set off to find out where it's coming from, discovering the source is new villain Allegro.

Bubbles meets a talking pony named Donny, who wants to be a unicorn, but things take a wrong turn when Donny transforms into a monster that threatens Townsville.

Buttercup adopts a New Age attitude after letting new villain Man-Boy escape and trashing up a New Age festival in a blind rage as a result of him calling her "princess". In order to defeat Man-Boy when he returns to take revenge, Buttercup aims to strike an order of balance between peace and struggle.

The Mayor of Townsville needs a new assistant after secretary Ms. Bellum gives notice. But after he hires Bianca Bikini, who just broke out of prison, she breaks her ape sister-in-arms, Barbarus, out of prison as well, then they kidnap the Powerpuff Girls! Now it's up to the Mayor to save them.

A lesson for Bubbles by Buttercup backfires when Pack Rat steals Octi. She later admits that she hid him to teach Bubbles a lesson of letting go.

Bubbles fights the villainous Pack Rat (from "Little Octi Lost") using her cybernetic cast covering a broken arm, which she calls Armsy. When she learns that Armsy has unique properties of its own, she becomes obsessed with it and begins to rely on it frequently.

Buttercup and Bubbles "level up" during a fight and develop the ability to create solid energy constructs (bright blue for Bubbles, and bright green for Buttercup) in any shape or form they wish. As she loses patience in a battle, Blossom fully taps into her own abilities and develops the power to create bright pink energy constructs that unusually take on the shape of regular household items.

The Mayor hosts a beauty pageant, and Mojo Jojo, The Gangreen Gang, Fuzzy Lumpkins, Princess and Bubbles participate to win a mysterious tiara that is actually cursed by Him. Bubbles succeeds in using her high-frequency singing voice to shatter the tiara when it possesses Princess.

The Powerpuff Girls go to Pokey Oaks Kindergarten on the first day of school, and find out it's closed due to an earlier accident caused by Bubbles, so they get sent to an elementary school. Unfortunately, the big kids keep calling the girls babies due to their short height, so they ask the Professor to make a potion that ages them. And even worse, they consume too much of it and turn into old grannies.

Note: This episode promptly takes place before Princess Buttercup.

The Powerpuff Girls try to split up the Professor and his girlfriend, who has a thing about spiders. But after the break-up and when Buttercup shows the Professor's ex-girlfriend a song he made for her, the ex-girlfriend's feelings of love transform her into a giant spider that goes on a rampage throughout Townsville.

Blossom unleashes evil spirits from an ancient, mystical chest with her spring cleaning, and when she says a sentence with the word "hopeless", a fairy-like being named Hope tells her that only a strange foreign sentence—which is "τα λέμε" ("ta léme", which means "See you!" in Greek)—can put the spirits back in the chest, but only if she agrees to do things her sisters' way.

Blossom tries to impress a famous scientist at the school science fair. Meanwhile, Bubbles and Buttercup try to find a "ghost horse". Then, after Blossom reveals her latest creation, the scientist reveals that he's actually a centaur named Janitaur, and he uses the invention to turn everybody—including the girls—into half-animals.

The girls' befriend a new classmate named Jemmica. She seems cool, but is actually a thief taking advantage of the girls' abilities to steal a priceless artifact of great power. The "best-friends-forever (BFF) necklaces" she gave them actually give her control over them.

From a storybook universe, Princess Bluebell tries to meet her Prince Charming but keeps ending up putting her life in danger; especially when she ends up in the modern-day era of Townsville.

Man-Boy returns, stealing all of Townsville's water to fuel his lawn. A distracted Buttercup misses the fight and has to rescue her sisters alone and toughen up more if she wants to beat Man Boy again.

The Amoeba Boys—with the help from a mysterious cybernetic villain named Silico—hack themselves into the Internet and try to take it down in another bid to make a name for themselves, so it's up to Bubbles to upload her sisters into the Internet to stop them.

After a series of mishaps that end up ruining her appearance (a botched picture day photo and botched haircut both courtesy of a dim-witted lunchlady, an allergic reaction to recalled makeup and a collision with a ceiling fan), Bubbles turns against her sisters and joins forces with Mojo Jojo; thus calling herself "Dark Bubbles".

Blossom and Bubbles come down with a case of spotted piglet fever, so the Professor gives them a combination of an antidote and a song. He then leaves Buttercup in charge of them, but her prevention from giving them the antidote/song combination causes Blossom and Bubbles to transform into giant warthogs. Eventually, Buttercup finally gives them the antidote/song combination, causing them to revert to normal.

Donny (from "Horn, Sweet Horn") stays with the girls for a week as part of a student exchange program, but at school, he starts hanging out with a girl named Chelsea, much to Bubbles' jealousy. But after Bubbles bends Donny's spoon in front of him and he runs out of the house, the girls find out that Chelsea lives in a volcano, which is actually Mojo Jojo's lair. They go there and see that Chelsea is actually a robot, engaging each other into a fight, and also see that Donny's magic is being drained for Mojo's death ray.

When Princess Morbucks enters the Student Body President race, a determined Blossom sinks to her level to secure a win-win for herself.

Bubbles takes home a new pet, despite her sisters' warnings.

When the Fashionistas launch a new line of brainwashing clothing that Blossom falls under the control of, it's up to the Professor to stop the fashion trend before it's too late.

When the Powerpuff Girls try a quick-fix on their neglected vegetable garden, they are left with a giant, mooching and excessively clumsy tomato worm they must care for.

Bubbles realizes that she and the Professor do not have a lot in common. To correct this, she takes him on a father-daughter day road trip across the city. However, Bubbles soon becomes suspicious that the Professor intends to dump her. Meanwhile, Blossom and Buttercup deal with Schedulebot and Buttercup buries him alive.

The Professor's new pillow invention comes alive and starts hunting him and the Girls. Despite their fright, the Powerpuff Girls have to stop this creepy monster-like invention before it escapes into the city.

When Blossom can't join her favorite school club, she imagines what her life would be like if she joined other clubs.

When a series of negative articles about the Powerpuff Girls are posted on the Internet, the girls track them back to Silico.

The Powerpuff Girls get a paper fortune teller and start predicting their futures by telling it secrets. Unfortunately, unknown to them it's another one of Him's plots, as they find out that all of the Professor's secrets will be exploited.

Against the Professor's orders, Bubbles and Buttercup fight the rainy day blues by playing in the lab and end up with more than they bargained for when they accidentally turn Blossom into various "past versions" of herself through the Professor's time dasher.

A living "spaghetti squash" gourd captures the Powerpuff Girls on Halloween, and they must tell him a scary story in order to break free.

The girls enter a battle of the bands contest, but Buttercup keeps smashing her guitars during band practice, when she goes to get her latest guitar fixed, the shop owner refuses to do so and Buttercup states she'll do anything for a new guitar.

After an accident in the lab, the girls become worried about the Professor's safety and seek to protect him from all of the potential dangers he could face.

After Princess Morbucks goes broke, it is up to Blossom to change her ways. Will this be the start of a new friendship for the Girls and Morbucks?

Jared Shapiro, an admirer of Blossom, gives her a letter displaying his feelings for her. However, thanks to Bubbles and Buttercup's teasing, she becomes nervous in wanting to give an answer to him. When a snow day comes around the next day, Blossom decides to use her ice breath to extend it-

A mysterious person comes to Townsville, challenging anyone who can be brave enough to try his swing set. Against the Professor's wishes, the girls take up the challenge and swing so high that they end up in an alternate dimension where everything is perfect.

Blossom neglects her promise to Bubbles when she takes on too many tasks, leaving Buttercup and Bubbles to fend for themselves when Bubbles' biome project turns into a monster.

When Donny the Unicorn is hunted by a seemingly unstoppable foe, the Powerpuff Girls have to find a way to save him before it's too late.

Note: This is the first 22-minute episode of the reboot series.

While volunteering at a retirement home, Buttercup meets an old woman who claims she used to be a superheroine called Green Wing.

When Bubbles' video becomes viral, she does her best to keep its popularity.

The Powerpuff Girls learn to appreciate each others's style after having to each fight solo.

While visiting the lake, Buttercup vows to capture a legendary uncatchable crawdad.

Princess Morbucks throws her sixth birthday party and being the only one not invited (and suspecting foul play), Blossom tries to keep Buttercup, Bubbles and the Professor at home so they won't go.

Blossom becomes jealous when Bubbles becomes the star of the school play.

Buttercup takes her game-winning at mini-golf ball too seriously, in spite of ominous warnings of dire consequences.

At the beach, the girls have a disagreement. Meanwhile, a team of sharks called the Bro Sharks arrive and the Powerpuff Girls eventually get challenged to a volleyball game which they must win to save the beach.

After breaking and burying Schedulebot for being too annoying, following the events of "Road Trippin'", Blossom and Buttercup try not to tell the Professor while Bubbles investigates.

Feeling inadequate as a superhero, Buttercup bulks up.

The Powerpuff Girls spend the day with the Professor at his boring office, only to find that the office comes with a terrible secret.

Bubbles tries to prove that she's responsible enough to own a dog.

When Buttercup tests into Honors Math, she tries to avoid being labeled a nerd.

When the girls go to camp, Blossom has a hard time leaving her schoolwork at home.

While going through the Professor's scrapbook, Bubbles starts to question if she's ever been a hero.

When a monster ruins their relaxing vacation, the Powerpuff Girls run into a familiar face.

The Powerpuff Girls have to battle Him after he causes Bubbles' imagination to run wild.

After getting sucked into Jared's favorite board game, Buttercup is forced to team-up with him in order to save her sisters.

Blossom gets a toothache one night, making her scared of the dentist. When Bubbles draws a smiley face on her toothache, Blossom gets tired. But as soon as the girls fall asleep, Blossom’s toothache turns green and gets bigger, turning her into a cactus-like monster. Blossom runs over Townsville, keeping everybody up all night. Professor takes her to the dentist, and as soon as Blossom’s toothache gets cured, she goes back to normal.

When Blossom makes a bad call, she becomes afraid to try again. Meanwhile, Mojo and Barbarus fall in love with each other even though Bianca does not accept.

Mojo and Barbarus announce their wedding, leading the Powerpuff Girls to suspect they are up to no good.

Part One – Find Your Bliss: Getting ready for the new Space Tow Truck movie, Bubbles keeps explaining to Blossom and Buttercup that Bliss exists, the two don’t seem to believe her though. At the theaters, an old-timey character breaks through the screen and the Girls prepare to fight him. Eventually after calling her multiple times, Bliss finally appears and defeats the villain, but the Professor, deeming her too dangerous, stuns her and knocks her out.
Part Two – Bliss Reminisce: Bliss' backstory is revealed, by the Professor, Bliss herself and even Mojo Jojo.
Part Three – Blisster Sister: When Bliss can't control her powers, the Girls must help her, whilst dealing with repeated attacks from the Gnat.
Part Four – Breaking Bliss: When the Professor thinks Bliss is not ready to fight crime, she must prove it by doing with the Girls; they are unaware that Mee (Bliss' pet elephant) is actually Him in disguise, wanting something bad to happen so that he can merge with Bliss and use her powers for his own ends.
Part Five – Blisstersweet Symphony: With Bliss possessed by Him, the Girls must save Bliss and stop Him once and for all before he splits Townsville and the Earth in two.

Note: This is the series' first one hour TV movie event.

Guest star: Bliss is played by Olivia Olson in the North American version, Toya Delazy in the African version,^[66] Alesha Dixon in the UK and Ireland version,^[67] and Wengie in the Australian version.^[68]

When the Mayor's mansion is stalked by a vicious monster, the Powerpuff Girls must step in to help.

On Generic Tree Lighting Day (Christmas), Mojo upsets a puppy orphanage by stealing their karaoke machine, but then when he gets home he falls asleep and has a dream that he is visited by the ghost forms of Blossom, Bubbles and Buttercup, A Christmas Carol-style.

When Bubbles is overworked, she uses her coding skills to come up with a new solution.

When Buttercup gets super lice, her sisters must battle them to save her.

Buttercup joins Jemmica in a quest for adventure.

The Powerpuff Girls must overcome their turbo hiccups to stop the Gnat's latest evil plan.

When Mojo kidnaps the Powerpuff Girls' favorite snuggle toys, he gets more than he bargained for.

When Bubbles joins the Derbytantes, Buttercup finds herself on the sidelines.

When Bubbles isn't her normal, bubbly self, her sisters don't know how to handle it.

A classy queen of etiquette makes the Utoniums question their superhero way of life.

After Bubbles gets blasted with Man Boy's beard ray, she wreaks havoc in the most manly and adorable way possible.

Blossom's skepticism is put to the test when she believes she's encountered a space alien.

After Mojo Jojo's latest creation threatens to blast him into tiny bits, the Powerpuff Girls are forced to take Mojo in.

Bliss returns, but with a parasitic alien on the loose in their school, she and the Powerpuff Girls have to find a way to stop it before the big dance.

Note: This episode premiered during Season 2's run.

Guest star: Bliss is played by Olivia Olson in the North American version, Toya Delazy in the African version, Alesha Dixon in the UK and Ireland version, and Wengie in the Australian version.

The Powerpuff Girls compete for the title of World's Greatest Superheroes!

When the Fashionistas unveil their new mind controlling perfume, the Powerpuff Girls must find a way to stop them before Townsville falls under their spell.

After being blasted by Duplikate, Blossom turns into a triple threat.

In an effort to make himself "great," Mojo steals the powers that make each of the Powerpuff Girls the heroes they are.

When Morbucks realizes that the Powerpuff Girls see her as a villain and not a friend, she sets out to turn the town against them.

Ms. Keane is nervous about a first date.

When Morbucks falls in love, she finds the first thing money can't buy.

When a mysterious rain cloud plagues Townsville, Bubbles learns things aren't what they seem.

Buttercup is knocked off-kilter by a mysterious force.

When an ancient prophecy spells doom for Townsville, the Powerpuff Girls must race to stop it.

The Powerpuff Girls compete in a race against some of their most vicious villains, to win whatever is in the Mayor's "Mysterious Box Of Mystery"; something that may reveal the awful truth about Jemmica.

After they get accused of a crime they didn't commit, the Powerpuff Girls and the Derbytantes have to find a way to clear their name! But Blossom feels the "Deathball way" isn't the way to do it.

After a chemical spill, the Powerpuff Girls and Mojo find themselves trapped together.

Buttercup must go it alone to save her family from a kidnapping.

When the Professor is kidnapped, the Powerpuff Girls must go to a mysterious island to save him.

Part One: Abra-Disaster: After defeating Mojo, Fuzzy, The Amoeba Boys, Pug-Faced Paulie and The Gnat for the umpteenth time, the Powerpuff Girls are confident they are unstoppable.
Part Two: Stone Cold Spider: With Townsville in peril, the girls are sent to the arctic on a dangerous mission to find the key to saving the day.
Part Three: Maze Daze: The girls must enter a cursed jungle temple to obtain the last Heart Stone. Meanwhile, when Bubbles gets separated from her sisters, she tries to act more like them.
Part Four: Heart to Heartstone: In the stunning conclusion, the girls' learn that Lester Van Luster has one more trick up his sleeve. Fortunately, they learn that they had the ability to defeat him all along.

Guest Star: Dwight Schultz as Lester Van Luster

On Halloween night, Morbucks summons a monster that she didn't expect.

The Powerpuff Girls must replace the Professor's Christmas present on Christmas Eve.

Buttercup is not a fan of Bubbles' newly created digital assistant, but must help her sisters in stopping Daisy when an attempt at reprogramming it causes it to go completely mad.

When a mysterious new ice cream flavor takes Townsville by storm, the Powerpuff Girls suspect there might be foul play.

When Bliss brings a new tech product to town, it's more powerful than imagined.

When The Powerpuff Girls tell Barry that he's a hero, he takes it way too far!

A new villain arrives in Townsville and gives the old villains an enticing offer.

A crash landing sends Townsville over the edge.

An alarmingly familiar cat burglar terrorizes Townsville.

When Buttercup loses the Professor's latest invention, she'll have to beat The Gangreen Gang at their own game to get it back.

The Professor makes new friends, but they might be the wrong crowd for him.

Bubbles and Buttercup make a deal without realizing the consequences.

Buttercup is tired of Bubbles following her everywhere.

A new superhero arrives in Townsville with a dark secret.

A trip to the supermarket has bizarre consequences.

The school play goes off the rails when the drama teacher interferes.

The Powerpuff Girls are tasked with keeping a priceless gem safe from thieves.

With Manboy on the loose, Donny must be prepared for anything.

When Princess Morbucks steals Octi, Bubbles' reaction surprises everyone, even her sisters.

When The Powerpuff Girls play soccer, the Professor goes overboard.

An extended version of the new theme song, including a retelling of the girls' origins.

Buttercup tries to shoot her garbage in the trash basketball style, but keeps failing.

Bubbles tries to make a beauty vlog, but Buttercup and Blossom keep getting in the way.

Blossom tries to rush to school, but faces many obstacles along the way.

To decide who gets to do the dishes, the Powerpuff Girls challenge each other to a game of ping pong.

Bubbles and Donny are asked by the Professor to get the mail, and they think it's a mission.

The Powerpuff Girls need to get a good night's rest before family photo day, but they just can't seem to fall asleep!

Mojo discovers the only thing more difficult than total world domination is DIY furniture!

Bubbles and Buttercup's good intentions are bad news for the cake Blossom is trying to bake.

Bliss uses her telekinetic powers to help the Professor make a more delicious dinner.

After using a repellent to temporarily hinder Blossom, Bubbles, and Buttercup, Mojo Jojo uses a teleportation device to teleport himself to Jump City in the Teen Titans Go! universe. There, he recruits Beast Boy and Cyborg to help him build his monkey army. The girls try to follow him, only to run into Raven, Starfire, and Robin. The Titans then proceed to rope the girls into a contest to see who's the better team, with stopping Mojo as the goal.

Note: This episode was produced by Warner Bros. Animation, making it the first episode produced by a studio other than Cartoon Network Studios since the 1998 Powerpuff Girls series episode "Superfriends".