Taxadien-5alpha-ol O-acetyltransferase

taxadien-5-alpha-ol O-acetyltransferase
Identifiers
EC no.2.3.1.162
CAS no.229032-29-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a taxadien-5alpha-ol O-acetyltransferase (EC 2.3.1.162) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + taxa-4(20),11-dien-5alpha-ol CoA + taxa-4(20),11-dien-5alpha-yl acetate

Thus, the two substrates of this enzyme are acetyl-CoA and taxa-4(20),11-dien-5alpha-ol, whereas its two products are CoA and taxa-4(20),11-dien-5alpha-yl acetate.

This enzyme participates in diterpenoid biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase. Other names in common use include acetyl coenzyme A:taxa-4(20),11(12)-dien-5alpha-ol O-acetyl, and transferase.

References

Further reading

  • Walker K, Ketchum RE, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau R (April 1999). "Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis". Archives of Biochemistry and Biophysics. 364 (2): 273–9. doi:10.1006/abbi.1999.1125. PMID 10190984.


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