TRAP1

TRAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRAP1, HSP 75, HSP75, HSP90L, TRAP-1, TNF receptor associated protein 1
External IDsOMIM: 606219; MGI: 1915265; HomoloGene: 9457; GeneCards: TRAP1; OMA:TRAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10131

68015

Ensembl

ENSG00000126602

ENSMUSG00000005981

UniProt

Q12931

Q9CQN1

RefSeq (mRNA)

NM_001272049
NM_016292

NM_026508

RefSeq (protein)

NP_001258978
NP_057376

NP_080784

Location (UCSC)Chr 16: 3.65 – 3.72 MbChr 16: 3.86 – 3.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.[5][6][7]


Interactions

TRAP1 has been shown to interact with EXT2,[8] EXT1[8] and Retinoblastoma protein.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126602 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005981 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem. 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318.
  6. ^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093.
  7. ^ "Entrez Gene: TRAP1 TNF receptor-associated protein 1".
  8. ^ a b Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594.
  9. ^ Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. 16 (9): 4691–9. doi:10.1128/MCB.16.9.4691. ISSN 0270-7306. PMC 231469. PMID 8756626.

Further reading


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