7318
74153
ENSG00000182179
ENSMUSG00000032596
P41226
n/a
NM_003335
NM_023738
NP_003326
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
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