UBE1L

UBA7
Identifiers
AliasesUBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
External IDsOMIM: 191325; MGI: 1349462; HomoloGene: 2502; GeneCards: UBA7; OMA:UBA7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7318

74153

Ensembl

ENSG00000182179

ENSMUSG00000032596

UniProt

P41226

n/a

RefSeq (mRNA)

NM_003335

NM_023738

RefSeq (protein)

NP_003326

n/a

Location (UCSC)Chr 3: 49.81 – 49.81 MbChr 9: 107.85 – 107.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. Bibcode:1993PNAS...90.6071K. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
  6. ^ a b "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

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