In enzymology, a sphingosine cholinephosphotransferase (EC 2.7.8.10) is an enzyme that catalyzes the chemical reaction

CDP-choline + sphingosine ${\displaystyle \rightleftharpoons }$ CMP + sphingosyl-phosphocholine

Thus, the two substrates of this enzyme are CDP-choline and sphingosine, whereas its two products are CMP and sphingosyl-phosphocholine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:sphingosine cholinephosphotransferase. Other names in common use include CDP-choline-sphingosine cholinephosphotransferase, phosphorylcholine-sphingosine transferase, cytidine diphosphocholine-sphingosine cholinephosphotransferase, and sphingosine choline phosphotransferase. This enzyme participates in sphingolipid metabolism.

• Fujino Y, Negishi T, Ito S (1968). "Enzymic synthesis of sphingosylphosphorylcholine". Biochem. J. 109 (2): 310–1. PMC 1186790. PMID 5679375.