The toponym is derived from the Old English for either "spying place" or the place of a person called "Speol". It was first recorded in the Cartularium Saxonicum in 1010 as Speoles byrig. In 1086 the Domesday Book recorded the village as Spelesberie.[2] Spelsbury has a group of almshouses built in 1688 by John Carry.[3] Coldron Mill, south-west of the village, is on a site where a mill has existed for at least a thousand years.[4] Winterberry Park built in 1725 by Thomas Archer is on the parish borders. In the village a drinking fountain in the shape of a shell commemorates Henry Dillon, 13th Viscount Dillon, who died in 1853.[5] The poet John Wilmot, 2nd Earl of Rochester and his wife Elizabeth Malet lived and are buried in Spelsbury.[6] The actor Sir Ben Kingsley lives in the village.[7]
Spelsbury was an ancient parish, which became a civil parish in 1866. Until 1985 the parish also included the hamlet of Fulwell, but in that year Fulwell was transferred to the civil parish of Enstone. At the same time the eastern part of Ditchley Park was transferred from the civil parish of Kiddington with Asterleigh to the parish of Spelsbury.[9]