Ambrose Godfrey (1660–1741), a German-born chemist, inventor of the fire extinguisher, and a collaborator of Robert Boyle,[5] lived and had a laboratory and pharmacy in the street from 1706 until his death.[1] A green plaque installed by the City of Westminster marks the site on the west side of the street at No. 31.[6]
John Ashburnham, 1st Baron Ashburnham, a landowner and politician, died at Southampton Street on 21 January 1710, aged 54. Charles Combe, the physician and numismatist, was born on 23 September 1743 in Southampton Street, where his father, John Combe, had a business as an apothecary. Sir William Schwenck Gilbert, the dramatist, librettist, poet, and illustrator, who collaborated with the composer Sir Arthur Sullivan in the Gilbert and Sullivan partnership, was born at 17 Southampton Street on 18 November 1836.
Goupil & Co., the London branch of the Paris-based art dealership Goupil & Cie, was located at 17 Southampton Street in the 19th century. The painter Vincent van Gogh worked here.[8] He arrived on 19 May 1873 to work for the manager Charles Obach.[9]
From August of that year while working here, he lived at 87 Hackford Road in Brixton, south London.[10]