Mayer started his career in 1982 in a group called Chévere Internacional, which he belonged to for 4 years. With the group, he toured all over Latin America and the United States. Once the tour ended, he returned to Mexico to complete his Business Administration degree at the Universidad Iberoamericana.
During that time he made commercials and fashion runways. He was invited to participate in the Heraldo awards as a dancer.
Later he created the concept of Solo Para Mujeres with Alexis Ayala. He combined his singing and acting activities with his business and artistic representation with Espectaculos Mayer. Solo Para Mujeres "Only for Women" is a male strip show where many male models, including him, take off their clothes in public and show nothing but a thong. He has made videos of these performances, one of which has been out on DVD in 2009.
In May 2004, he decided to take part in the second chapter of Big Brother VIP in its third edition; in which he ended in second place, beaten only by Roxana Castellanos. He has a son with actress Bárbara Mori, Sergio Jr.
In March 2007, he appeared in the music video for Ivy Queen's hit single "Que Lloren".