Weiss first became a member of the Bundestag in the 2009 German federal election.[1] In her first term from 2009 until 2013, she served on the Committee on Petitions; the Committee on Economic Cooperation and Development; the Subcommittee on Health in Developing Countries; and the Subcommittee on Civilian Crisis Prevention.
In the negotiations to form a Grand Coalition of Chancellor Angela Merkel's Christian Democrats (CDU together with the Bavarian CSU) and the SPD following the 2013 federal elections, Weiss was part of the CDU/CSU delegation in the working group on families, women and equality, led by Annette Widmann-Mauz and Manuela Schwesig. From 2014 until 2018, she was one of the deputy chairs of the CDU/CSU parliamentary group, under the leadership of chairman Volker Kauder.
In June 2017, Weiss voted against her parliamentary group’s majority and in favor of Germany’s introduction of same-sex marriage.[5]
In 2019, Weiss joined 14 members of her parliamentary group who, in an open letter, called for the party to rally around Merkel and party chairwoman Annegret Kramp-Karrenbauer amid criticism voiced by conservatives Friedrich Merz and Roland Koch.[6]