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SPV-400

SPV-400
Clinical data
Other namesSPV400
Routes of
administration		Parenteral[1]
Drug classTropomyosin receptor kinase B (TrkB) agonist

SPV-400 is a tropomyosin receptor kinase B (TrkB) agonist which is under development for the treatment of neurological disorders.[1][2][3] It is taken parenterally.[1] The preclinical pharmacokinetics of SPV-400 have been studied and described.[1][3] The drug is under development by Spave Science.[1][2] As of August 2025, it is in the preclinical research stage of development for neurological disorders.[1][2] The chemical structure of SPV-400 does not yet appear to have been disclosed.[1]

See also

References

  1. ^ a b c d e f g "SPV 400". AdisInsight. 1 August 2025. Retrieved 10 June 2026.
  2. ^ a b c "Delving into the Latest Updates on SPV-400 with Synapse". Synapse. 11 March 2026. Retrieved 10 June 2026.
  3. ^ a b Choi EJ, Renger J, Iuvone PM (8 April 2025). "Absorption, Distribution, Metabolism, And Excretion (ADME) And Pharmacokinetic (PK) Properties of SPV-400, a Novel Tropomyosin Kinase Receptor B (TrkB) Activator (P9-2.002)". Neurology. 104 (7_Supplement_1) 2910. doi:10.1212/WNL.0000000000210660. ISSN 0028-3878.
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