SLC27A5

SLC27A5
Identifiers
AliasesSLC27A5, ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2, solute carrier family 27 member 5
External IDsOMIM: 603314; MGI: 1347100; HomoloGene: 7596; GeneCards: SLC27A5; OMA:SLC27A5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10998

26459

Ensembl

ENSG00000083807

ENSMUSG00000030382

UniProt

Q9Y2P5

Q4LDG0

RefSeq (mRNA)

NM_012254
NM_001321196

NM_009512

RefSeq (protein)

NP_001308125
NP_036386

NP_033538

Location (UCSC)Chr 19: 58.48 – 58.51 MbChr 7: 12.72 – 12.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.[5][6][7]

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083807 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030382 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi:10.1006/mgme.1999.2883. PMID 10479480.
  6. ^ Steinberg SJ, Mihalik SJ, Kim DG, Cuebas DA, Watkins PA (Jun 2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J Biol Chem. 275 (21): 15605–8. doi:10.1074/jbc.C000015200. PMID 10749848.
  7. ^ a b "Entrez Gene: SLC27A5 solute carrier family 27 (fatty acid transporter), member 5".

Further reading


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