PROFILPELAJAR.COM

SH3KBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BZ8, 2K6D, 2K9G, 2O2O, 2YDL, 5ABS, 2N64
Identifiers
Aliases	SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
External IDs	OMIM: 300374; MGI: 1889583; HomoloGene: 10971; GeneCards: SH3KBP1; OMA:SH3KBP1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	19,887,600 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	158,761,065 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; myocardium of left ventricle; ; mucosa of ileum; ; lateral nuclear group of thalamus; ; skin of arm; ; cardiac muscle tissue of right atrium; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; blood; ; white blood cell;
	Top expressed in
	thymus; ; zygote; ; myocardium of ventricle; ; right ventricle; ; granulocyte; ; cardiac muscles; ; atrioventricular valve; ; secondary oocyte; ; stroma of bone marrow; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; protein binding;
Cellular component	cytosol; membrane; cell-cell junction; focal adhesion; plasma membrane; endocytic vesicle; synapse; cell junction; neuron projection; cytoskeleton; cytoplasmic vesicle membrane; cytoplasmic vesicle; cytoplasm;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; endocytosis; cell-cell signaling; cytoskeleton organization; regulation of cell shape; cell migration; apoptotic process; membrane organization; axon guidance; actin filament organization;
	Sources:Amigo / QuickGO
Orthologs
	30011
	58194
	ENSG00000147010
	ENSMUSG00000040990
	Q96B97; Q5JPT2
	Q8R550
NM_001024666; NM_001184960; NM_031892; NM_001353890; NM_001353891;
	NM_001353892; NM_001353893; NM_001353894; NM_001353895; NM_001353897
NM_001135727; NM_001135728; NM_001290661; NM_001290664; NM_021389;
	NM_001374701
NP_001019837; NP_001171889; NP_114098; NP_001340819; NP_001340820;
	NP_001340821; NP_001340822; NP_001340823; NP_001340824; NP_001340826
NP_001129199; NP_001129200; NP_001277590; NP_001277593; NP_067364;
	NP_001361630
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85^[5], in rodents - Ruk^[6]) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.^[7]^[8]

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]^[9]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,^[10] Grb2,^[11]^[12] SH3GLB2,^[13]^[14] SH3GL3,^[13] SH3GL2,^[14] BCAR1,^[10] Epidermal growth factor receptor,^[14]^[15] CBLB,^[15] Cbl gene,^[10]^[12]^[13]^[14]^[15] SOS1,^[10] CRK^[10] and PAK2.^[16]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147010 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040990 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Database GH. "SH3KBP1 Gene - GeneCards | SH3K1 Protein | SH3K1 Antibody". www.genecards.org. Retrieved 2017-12-28.
^ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
^ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
^ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
^ "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1".
^ ^a ^b ^c ^d ^e Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
^ Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
^ ^a ^b Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
^ ^a ^b ^c Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID 11894096. S2CID 4389099.
^ ^a ^b ^c ^d Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID 11894095. S2CID 635702.
^ ^a ^b ^c Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
^ Kurakin AV, Wu S, Bredesen DE (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". The Journal of Biological Chemistry. 278 (36): 34102–9. doi:10.1074/jbc.M305264200. PMID 12829691.