In 1899 Doyne discovered colloid bodies lying on Bruch's membrane that appeared to merge, forming a mosaic pattern that resembled a honeycomb. Afterwards, this disorder was referred to as "Doyne's honeycomb choroiditis". Today this condition is known to be a rare hereditary form of macular degeneration that results in progressive and irreversible loss of vision. Other names for the disorder are: "maculardrusen", "malattia leventinese", "dominant radial drusen" and "Doyne honeycomb retinal dystrophy".
In 1889, he was the first physician to describe angioid streaks, a disorder that affects Bruch's membrane, the innermost layer of the choroid.
Two years after his death in 1916, a prized distinction in British ophthalmologic medicine known as the "Doyne Memorial Lecture" was established.
He married Gertrude Hope Hollings, daughter of John Hollings of The Watchetts, Surrey, and had two sons including Philip, who was an ophthalmologist like his father.[4]