Ro 3-0419

Ro 3-0419
Names
Preferred IUPAC name
Diethyl quinolin-3-yl phosphate
Other names
3-(Diethoxyphosphinyloxy)-quinoline
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C13H16NO4P/c1-3-16-19(15,17-4-2)18-12-9-11-7-5-6-8-13(11)14-10-12/h5-10H,3-4H2,1-2H3
    Key: LHRQAYKGKTYZRY-UHFFFAOYSA-N
  • CCOP(=O)(OCC)Oc1cc2ccccc2nc1
Properties
C13H16NO4P
Molar mass 281.248 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Highly toxic
Lethal dose or concentration (LD, LC):
1 mg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It is the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, resulting in its ability to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.[1]

See also

References

  1. ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
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