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Progastricsin also known as pepsinogen C or pepsinogen II is a pepsinogen precursor of the enzyme gastricsin that in humans is encoded by the PGC gene.^[1]^[2]^[3]^[4]

Function

Progastricsin is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.^[4]

Clinical significance

Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.^[4]

References

^ Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K (January 1988). "Primary structure of human pepsinogen C gene". J. Biol. Chem. 263 (3): 1382–5. doi:10.1016/S0021-9258(19)57314-8. PMID 3335549.
^ Pals G, Azuma T, Mohandas TK, Bell GI, Bacon J, Samloff IM, Walz DA, Barr PJ, Taggart RT (February 1989). "Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter". Genomics. 4 (2): 137–48. doi:10.1016/0888-7543(89)90292-9. PMID 2567697.
^ Taggart RT, Cass LG, Mohandas TK, Derby P, Barr PJ, Pals G, Bell GI (January 1989). "Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A". J. Biol. Chem. 264 (1): 375–9. doi:10.1016/S0021-9258(17)31268-1. PMID 2909526.
^ ^a ^b ^c "Entrez Gene: PGC progastricsin (pepsinogen C)".

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