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The Premios 40 Principales for Best America Best North Act is an honor presented annually at the Los 40 Principaless, a ceremony that recognizes excellence, creates a greater awareness of cultural diversity and contributions of Latino artists in the international scene.

This is a list of the Los Premios 40 Principales winners and nominees for Best America Best North Act.

Year	Winner	Other nominees
2012	Vazquez Sounds	León Larregui Eme 15 Enjambre Río Roma

• Official site