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The 2012 event was the seventh edition of Los Premios 40 Principales, created by Los 40 Principales to honor the best in Spanish and international music. For the first time, Los Premios 40 Principales América was run as a separate event.

Artist(s)	Song(s)
Pitbull	"Sube la mano p'arriba" "Don't Stop the Party"
Cali & El Dandee	"Yo te esperaré" "No hay dos sin tres (Gol)"
La Oreja de Van Gogh	"La niña que llora en tus fiestas" "Otra vez me has sacado a bailar"
Auryn	"Don't Give Up My Game"
Pablo Alborán	"Te he echado de menos" "Tanto"
José de Rico Henry Mendez	"Rayos de sol" "Noche de estrellas"
Alejandro Sanz	"No me compares" "Mi marciana" (with Leire Martínez, Chila Lynn and Bebe)
The Lion King cast	"He Lives in You"
Maldita Nerea	"La respuesta no es la huida" "¿No podíamos ser agua?"
Alicia Keys	"New Day" "Girl on Fire" "Brand New Me" "Looking for Paradise" (with Alejandro Sanz)
Taylor Swift	"Love Story" "We Are Never Ever Getting Back Together"
David Guetta	"Titanium" "She Wolf (Falling to Pieces)" "Just One Last Time" (with Taped Rai)

• Efecto Pasillo — "Pan y Mantequilla"
• Jose de Rico (featuring Henry Mendez) — "Rayos de sol"
• Alejandro Sanz — "Se Vende"
• Pablo Alborán — "Te He Echado de Menos"
• Juan Magan (featuring Belinda) — "Te Voy a Esperar"

• Carlos Jean — "BlackStar"
• La Oreja de Van Gogh — "Cometas Por El Cielo"
• Macaco — "Love Is The Only Way"
• Alejandro Sanz — "No Me Compares"
• Pablo Alborán — "Te He Echado de Menos"

• Estopa — Estopa 2.0
• Macaco — El Murmullo del Fuego
• Pablo Alborán — En Acústico
• Auryn — Endless Road, 7058 (Upcoming)
• Alejandro Sanz — La Música No Se Toca

• Alejandro Sanz
• Estopa
• Macaco
• Melendi
• Pablo Alborán

• Auryn
• Chila Lynn
• Efecto Pasillo
• Lagarto Amarillo
• Xuso Jones

• Carlos Jean — Live Experience Tour 2012
• Estopa — Estopa: Tour 2.0
• La Oreja de Van Gogh — Tour 2012
• Maldita Nerea — Gira Mucho + Fácil
• Melendi — Tour 2012

• Crossfire — "Lady"
• Cali & El Dandee (featuring David Bisbal) — "No Hay 2 Sin 3 (Gol)"
• Tacabro — "Tacata'"
• Sie7e — "Tengo Tu Love"
• Cali & El Dandee — "Yo Te Esperaré"

• Cali & El Dandee
• Jennifer Lopez
• Juanes
• Pitbull
• Shakira

• Loreen — "Euphoria"
• Carly Rae Jepsen — "Call Me Maybe"
• Maroon 5 (featuring Christina Aguilera) — "Moves like Jagger"
• Gotye (featuring Kimbra) — "Somebody That I Used to Know"
• Adele — "Someone like You"

• Coldplay — Mylo Xyloto
• David Guetta — Nothing but the Beat 2.0
• Maroon 5 — Overexposed
• Rihanna — Talk That Talk
• Flo Rida — Wild Ones

• Alicia Keys
• David Guetta
• Flo Rida
• Maroon 5
• Taylor Swift

• Carly Rae Jepsen
• Fun
• Gotye
• Nicki Minaj
• One Direction

• Best 21st Century's Spanish Artist: Alejandro Sanz
• Best last decade's American singer-songwriter : Alicia Keys
• Most influential artist and producer of the Latin World: Pitbull

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Los Premios 40 Principales América is Latin American version of Los Premios 40 Principales. The first edition for awards show was held on November 30, 2012, in Veracruz, Mexico.

• Jesse & Joy — "¡Corre!"
• Cali & El Dandee — "Yo Te Esperaré"
• Alejandro Sanz — "No Me Compares"
• Daddy Yankee — "Lovumba"
• J Alvarez — "La Pregunta"

• Juanes — Juanes MTV Unplugged
• Wisin & Yandel — Líderes
• Daddy Yankee — Prestige
• Jesse & Joy — ¿Con Quién Se Queda El Perro?
• Zoé — MTV Unplugged/Música de Fondo

• Reik
• Tan Biónica
• El Tambor de la Tribu
• Jesse & Joy
• Shakira

• Wisin & Yandel
• Daddy Yankee
• Don Omar
• Cali & El Dandee
• Pitbull

• León Larregui
• Vazquez Sounds
• Eme 15
• Enjambre
• Río Roma

• Iván Barrios
• Percance
• El Tambor de la Tribu
• Gánster
• Ale Fernández y la Suite Estéreo

• Tan Biónica
• Cali & El Dandee
• Denise Rosenthal
• Buxxi
• Maluma

• Michel Teló — "Ai Se Eu Te Pego"
• Maroon 5 (featuring Wiz Khalifa) — "Payphone"
• Gotye (featuring Kimbra) — "Somebody That I Used to Know"
• Rihanna — "Where Have You Been"
• Carly Rae Jepsen — "Call Me Maybe"

• One Direction
• Maroon 5
• Rihanna
• Katy Perry
• Adele

• One Direction
• Gotye
• Michel Teló
• Carly Rae Jepsen
• Calvin Harris

• David Guetta
• Calvin Harris
• Avicii
• Flo Rida
• LMFAO