Polycystin 1 (PC1) is a protein that in humans is encoded by the PKD1 gene. Mutations of PKD1 are associated with most cases of autosomal dominant polycystic...

Polycystin-2 (PC2) is a protein that in humans is encoded by the PKD2 gene. The gene PKD2 also known as TRPP2, encodes a member of the polycystin protein...

Polycystin refers to one of the following proteins: Polycystin-1 (PKD1) Polycystin-2 (PKD2) Polycystine This disambiguation page lists articles associated...

Polycystin 1 like 1, transient receptor potential channel interacting is a protein that in humans is encoded by the PKD1L1 gene. This gene encodes a member...

The Polycystin Cation Channel (PCC) Family (TC# 1.A.5) consists of several transporters ranging in size from 500 to over 4000 amino acyl residues (aas)...

disease 1 (PKD1)-like, contains polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal...

that in humans is encoded by the PKD2L1 gene. TRPP2 is a member of the polycystin protein family. TRPP2 contains multiple transmembrane domains, and cytoplasmic...

cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function in a common molecular...

domain was first identified in the polycystic kidney disease protein, polycystin-1 (PKD1 gene), and contains an Ig-like fold consisting of a beta-sandwich...

formation are tied to abnormal cilia-mediated signaling. The polycystin-1 and polycystin-2 proteins appear to be involved in both autosomal dominant and...

of membrane ion channels. Recent research investigates the function of polycystin-2, the inositol trisphosphate receptor, and the ryanodine receptor. Ehrlich...

Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS...

variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain...

caused by a primary defect in vascular polycystin-1. In collaborative studies, he also showed that polycystin-2, the other gene product defective in ADPKD...

reduction in portal pressure and a decreased risk of variceal bleeding. Polycystin defects increase intracellular cAMP, secondary messenger for vasopressin...

JL, Iatrino R, Su X, Koon SJ, et al. (October 2013). "Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients...

tyrosine-(Y)-phosphorylation regulated kinase 1A EPCIP: encoding exosomal polycystin-1-interacting protein ERG: encoding protein transcriptional regulator...

suggested to lead to cystogenesis include a germline mutation in one of the polycystin gene alleles, a somatic second hit that leads to the loss of the normal...

"Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5):...

putative target proteins of triptolide have been reported, including polycystin-2, ADAM10, DCTPP1, TAB1, and XPB. Multiple triptolide-resistant mutations...

Clinic Shillingford, Jonathan M. (2006). "The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney...

gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting...

Reg group None VIII Chondrolectin, Layilin None IX Tetranectin None X Polycystin WSC, REJ, PKD domains XI Attractin (ATRN) PSI, EGF and CUB domains XII...

Exosomal polycystin-1-interacting protein is a protein that, in humans, is encoded by the EPCIP gene. EPCIP is found on human chromosome 21, and it is...

homology: classical (TRPC), vanilloid receptors (TRPV), melastatin (TRPM), polycystins (TRPP), mucolipins (TRPML), and ankyrin transmembrane protein 1 (TRPA)...

CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2". J. Biol. Chem. 275 (42): 32888–93. doi:10.1074/jbc.M006624200. PMID 10913159...

K (2005). "Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2)". Pflügers Arch. 451 (1): 277–85. doi:10.1007/s00424-005-1469-4...

hdl:1765/56571. PMID 10931041. S2CID 3083613. Wilson PD (April 2001). "Polycystin: new aspects of structure, function, and regulation" (PDF). Journal of...

conserved signal and GTPase complex are required for the ciliary transport of polycystin-1". Molecular Biology of the Cell. 22 (18): 3298. doi:10.1091/mbc.e11-01-0082...

doi:10.1016/S0959-8049(00)00158-1. PMID 10959047. Wilson PD (April 2001). "Polycystin: new aspects of structure, function, and regulation". Journal of the American...

PMC 15822. PMID 10077564. Li Q, Shen PY, Wu G, Chen XZ (Jan 2003). "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor". Biochemistry...

Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96...

5-triphosphate receptor Ca2+ channels, transient receptor potential Ca2+ channels, polycystin cation channels, glutamate-gated ion channels, calcium-dependent chloride...

C5orf28 [8] TimeTree Data on Date of Divergence Valentine, Megan Smith, "Polycystin-2 (PKD2), Eccentric (XNTA), and Meckelin (MKS3) in the Ciliated Model...

ciliopathy is ADPKD, which is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and -2, respectively. These proteins are essential for the mechanosensory...

Mendes S, Gühmann M, et al. (December 2018). "Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance". eLife...

collecting ducts and cholangiocytes of bile ducts, and show similarity to polycystins and several other ciliopathy proteins. FPC is also found to be expressed...

Li HP, Wilson PD (December 2000). "Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation". Biochimica...

PC1 may refer to: Furin, an enzyme Proprotein convertase 1, an enzyme Polycystin 1, a protein in humans associated with autosomal dominant polycystic kidney...

nonmechanoreceptor potential C (nonpC), and the more distant cousins, the polycystins and mucolipins. A representative list of members belonging to the TRP-CC...

Pretoria, South Africa Pry (software), Read, Evaluate, and Print Ruby code Polycystin-related Y protein (PRY), found within the Y chromosome Pry (disambiguation)...

"The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease". Cells. 5 (1): 3...

Hofmann K, Bork P (August 1999). "A latrophilin/CL-1-like GPS domain in polycystin-1". Curr. Biol. 9 (16): R585–8. doi:10.1016/S0960-9822(99)80379-0. PMID 10469603...

as: LRR_8 (leucine-rich repeat), LRR_RI (ribonuclease inhibitor), PCC (polycystin cation channel protein) Super family, and Ig (immunoglobulin). The predicted...

photographs of her drawings were included in Figures of Remarkable Forms of Polycystins, or Allied Organisms, in the Barbados Chalk deposit in 1860–1861, followed...

doi:10.1016/S0959-8049(00)00158-1. PMID 10959047. Wilson PD (April 2001). "Polycystin: new aspects of structure, function, and regulation". Journal of the American...

novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699...

"Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5):...

channel family 1.A.4 Transient receptor potential Ca2+ channel family 1.A.5 Polycystin cation channel family 1.A.6 Epithelial Na+ channel family 1.A.7 ATP-gated...

Runping; Lin, Fang; Huang, Chou-Long (August 2022). "Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic...

"Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". The Journal of Cell Biology...

conserved signal and GTPase complex are required for the ciliary transport of polycystin-1". Molecular Biology of the Cell. 22 (18): 3289–3305. doi:10.1091/mbc...

superfamily: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), TRPA (ankyrin), and TRPN (NOMPC-like). TRP proteins...

are the obligate site of action for proteins such as Hedgehog, and the polycystins: by influencing ciliary stability, NEDD9 is positioned to affect these...

regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway". Human Molecular Genetics. 18 (1): 151–63. doi:10...

2006). "Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin". Human Molecular Genetics. 15 (22): 3280–92. doi:10...

Robertis EM, Wessely O (2010). "The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity". Development. 137 (7):...