Mokoto was born on 25 February 1973[1] in Mafikeng in the former Western Transvaal, where she grew up.[2] She worked for the North West branch of the African National Congress (ANC) as provincial media liaison officer from 1997 to 2004.[3] During that time she was also an active member of the party, serving on the National Executive Committee of the ANC Youth League and the Provincial Executive Committee of the ANC Women's League. She was also elected to a term as secretary of the mainstream ANC's branch in Tlhabologa, North West.[3]
On 2 September 2009, Mokoto was elected as Executive Mayor of Ngaka Modiri Molema District Municipality in the North West. She succeeded Themba Ngwabeni, who had been sacked amid service delivery protests and financial problems; the latter had also led the provincial government to place the municipality under administration.[2] Mokoto served less than two years in the mayoral office; she was replaced by Phaladi Saku after the 2011 local elections.[6]
At the ANC's 53rd National Conference in December 2012, Mokoto was elected to a five-year term as a member of the party's National Executive Committee, its 80-member executive organ. She received 1,644 votes from among the 4,500 voting delegates.[7]