PPP2R5E

PPP2R5E
Identifiers
AliasesPPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon, B56epsilon, B56E
External IDsOMIM: 601647; MGI: 1349473; HomoloGene: 55962; GeneCards: PPP2R5E; OMA:PPP2R5E - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5529

26932

Ensembl

ENSG00000154001

ENSMUSG00000021051

UniProt

Q16537

Q61151

RefSeq (mRNA)

NM_012024

RefSeq (protein)

NP_036154

Location (UCSC)Chr 14: 63.37 – 63.54 MbChr 12: 75.5 – 75.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.[5][6]

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.[6]

Interactions

PPP2R5E has been shown to interact with PPP2R1B[7] and PPP2CA.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154001 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021051 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
  6. ^ a b "Entrez Gene: PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform".
  7. ^ a b McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
  8. ^ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading


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