Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. It is called "non-homologous" because the break ends are directly...

NHEJ modifies and ligates the damaged ends regardless of homology. In terms of DSB repair pathway choice, most mammalian cells appear to favor NHEJ rather...

non-homologous end joining (NHEJ) pathway are more sensitive to prolonged desiccation during stationary phase than wild-type strains. NHEJ appears to be the preferred...

joining (MMEJ), also known as alternative nonhomologous end-joining (Alt-NHEJ) is one of the pathways for repairing double-strand breaks in DNA. As reviewed...

non-homologous end joining (NHEJ), microhomology-mediated end joining (MMEJ), and homologous recombination (HR): In NHEJ, DNA Ligase IV, a specialized...

ligated by the NHEJ pathway, but resection of a few nucleotides inhibits the NHEJ pathway and commits DNA repair to the HR pathway. The NHEJ pathway is involved...

involved in the non-homologous end joining (NHEJ) pathway to repair DNA double strand breaks (DSBs). NHEJ requires two main components to achieve successful...

through homology-directed recombination (HDR) or non-homologous end joining (NHEJ), resulting in targeted mutations. The development of CRISPR gene editing...

pathways are HRR homologous recombinational repair, SSA sub-pathway of HRR, NHEJ non-homologous end joining, BER base excision repair, TLS translesion synthesis...

HSC quiescence. Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because...

non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen...

homologous DNA is absent, another process called non-homologous end joining (NHEJ) takes place instead. HDR is important for suppressing the formation of cancer...

Nueil-sur-Layon (French pronunciation: [nɥɛj syʁ lɛjɔ̃] , literally Nueil on Layon) is a former commune in the Maine-et-Loire department in western France...

role in generating these translocations is the non-homologous end joining (NHEJ) pathway. When this pathway functions appropriately, it restores a DNA double-strand...

repaired by non-homologous end joining (NHEJ) or homology directed repair (HDR). However, in some contexts, NHEJ and HR are insufficient and TMEJ is the...

joining (NHEJ) pathway of DNA repair. Patients with XLF mutations also have immunodeficiency due to a defect in V(D)J recombination, which uses NHEJ to generate...

Nueil-sous-Faye (French pronunciation: [nɥɛj su fɛ], literally Nueil under Faye) is a commune in the Vienne department in the Nouvelle-Aquitaine region...

expression. Ligase IV is a critical component of the non-homologous end joining (NHEJ) mechanism that repairs DNA double-strand breaks. It is employed in repairing...

Nueil-les-Aubiers (French pronunciation: [nɥɛj le.z‿obje]) is a commune in the Deux-Sèvres department in western France. In 1996 it was twinned with the...

Meanwhile, Rif2 and Rap1 inhibit NHEJ: knocking out Rif2 or Rap1 results in longer telomeres as measured by PCR, indicating that NHEJ occurred. These knockout...

joining (NHEJ) or homologous recombination (HR). A-type lamins promote genetic stability by maintaining levels of proteins that have key roles in NHEJ and...

introduces a DNA double strand break, which is then followed by gene modification via homologous recombination (HDR) or non-homologous end joining (NHEJ)....

causes mutation. Non-homologous end joining (NHEJ) is a major pathway for repairing double-strand breaks. NHEJ involves removal of a few nucleotides to allow...

43 (TDP-43), is a critical component of the non-homologous end joining (NHEJ) enzymatic pathway that repairs DNA double-strand breaks in pluripotent stem...

theta-mediated end joining (TMEJ) or through non-homologous end joining (NHEJ). NHEJ is a DNA repair mechanism which, unlike homologous recombination, does...

"c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias". Molecular...

non-homologous end joining (NHEJ) DNA repair systems. It is much more error-prone than the more complex eukaryotic system of NHEJ, which uses multiple enzymes...

alterations associated with NHEJ repair. The frequency of epigenetic alterations causing repression of a gene after an NHEJ repair of a DNA double-strand...

double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to humans...

Artemis nuclease, a member of the ubiquitous non-homologous end joining (NHEJ) pathway for DNA repair. Several other enzymes are known to be involved in...

will occur is the repair mechanism known as non-homologous end joining (NHEJ). Illegitimate recombination is a natural process which was first found to...

retrovirus infection. MRI-2 may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2...

end joining (NHEJ), non-allelic homologous recombination (NAHR), or the breakage-fusion-bridge cycle. Non-homologous end joining (NHEJ) In the non-homologous...

repair this double stranded break, often through non-homologous end joining (NHEJ), which involves directly ligating the two cut ends together. This may be...

kinase signaling, ATR kinase signaling, non-homologous end-joining (NHEJ), alt-NHEJ, C-NHEJ, 5' resection, and homology directed repair (HDR). These repair...

reduce HRR, SSA or NHEJ leukemia, lymphoma, breast Nijmegen breakage syndrome NBS (NBN) NHEJ lymphoid cancers MRE11A MRE11 HRR and NHEJ breast Bloom syndrome...

accompanied by at least four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure)...

joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote...

non-homologous end joining (NHEJ). Lig4 deficiency in the mouse causes a progressive loss of HSCs during aging. These findings suggest that NHEJ is a key determinant...

NHEJ is efficient but inaccurate. Sealing of blunt DNA ends within a functional gene sequence occurs with a mutation frequency of about 50%. NHEJ is...

repair of the double-stranded break by means of non-homologous end joining (NHEJ) or POLQ/polymerase theta-mediated end-joining (TMEJ). These end-joining...

activates damage-signaling pathways that may lead to non-homologous end joining (NHEJ), homology directed repair (HDR), end-to-end fusions, genomic instability...

DNA-dependent protein kinase (DNA-PK) and XLF/Cernunnos, which are also required for NHEJ. The crystal structure of the Lig4/XRCC4 complex has been resolved. Defects...

binding. TDP-43 protein is a key element of the non-homologous end joining (NHEJ) enzymatic pathway that repairs DNA double-strand breaks (DSBs) in pluripotent...

or microhomologous repair mechanisms such as non-homologous end joining (NHEJ) and microhomology-mediated break induced repair (MMBIR) dominate double...

sequence of interest into the genome. Since NHEJ is more efficient than HDR, most DSBs will be repaired via NHEJ, introducing gene knockouts. To increase...

elements of homologous recombination (HR) and non-homologous end-joining (NHEJ) repair. These transcriptional responses are crucial for the DNA damage response...

non-homologous end joining (NHEJ) DNA repair. As shown by Shamanna et al., WRN is recruited to double-strand breaks (DSBs) and participates in NHEJ with its enzymatic...

two principal processes. The first process, non-homologous end joining (NHEJ), can join the two broken ends of DNA in the G1, S and G2 phases of interphase...

double-strand breaks (DSBs) by the process of non-homologous end joining (NHEJ). DSBs are one of the most significant types of DNA damage leading to genome...

two principal processes. The first process, non-homologous end joining (NHEJ), can join the two broken ends of DNA in the G1, S and G2 phases of interphase...

nucleotides during non-homologous end joining (NHEJ), a pathway of DNA double-strand break (DSB) repair. NHEJ is the main pathway in higher eukaryotes for...

the action of RM-systems in bacteria, and the non-homologous end-joining (NHEJ) that follows the use of ZFN without a repair template. Examples of restriction...

of a homologous template, be repaired by non-homologous end-joining (NHEJ). NHEJ repairs DSBs by joining the two ends together and usually produces no...

domain exon is rejoined through a process called non-homologous end joining (NHEJ) to the desired constant region (γ, α or ε). This process results in an immunoglobulin...

end-joining (NHEJ) or homology-directed repair (HDR) pathways. While HDR is expected to introduce a consistent modification to the genome, NHEJ can introduce...

pathway, targeted-mutagenesis uses Non-Homologous-End-Joining (NHEJ) of broken DNA. NHEJ is an error-prone DNA repair pathway, meaning that when it repairs...

that summons the cell's DNA repair mechanisms (non-homologous end joining (NHEJ) and homologous recombination (HR)) and leads to site-specific modifications...

two DNA repair pathways: NER and NHEJ. If activation of NEDD8 is inhibited, cells with induced deficiency of NER or NHEJ may then die because of deficient...

in the direction of repair by the process of non-homologous end joining (NHEJ). The role of BRCA1-A appears to be to bind BRCA1 with high affinity and...

accompanied by at least four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure)...

one is not, then the sequence will undergo non-homologous end joining (NHEJ). NHEJ often results in insertions or deletions within the gene of interest...

repair enzymes to fix any damage. As a result, non-homologous end joining (NHEJ), an error-prone repair process, becomes the main repair mechanism, increasing...

pathways: homologous recombinational repair (HRR), non-homologous end joining (NHEJ), and nucleotide excision repair (NER). DNA damage is considered to be the...

repaired by the imprecise repair mechanisms of non-homologous end joining (NHEJ) or microhomology-mediated end joining (MMEJ) instead of high fidelity HR...

dimethylation at Lys-36 at double-strand break locations, a signal enhancing NHEJ repair. Anthropoid primates, including humans, have a version of the protein...

are homologous recombinational repair (HR) and nonhomologous end joining (NHEJ). Macrophage-internalized M. tuberculosis is able to persist if either of...

AH, Zhang B, et al. (March 2016). "Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing". Scientific...

repair process of non-homologous end joining (NHEJ). WRN protein also physically interacts with the major NHEJ factor X4L4 (XRCC4-DNA ligase 4 complex). X4L4...

IV-dependent non-homologous end joining (NHEJ). DNA ligase III-alpha participates in a minor alternative NHEJ pathway that generates chromosomal translocations...

a double-stranded break which is repaired by non-homologous end joining (NHEJ). This procedure is very error-prone and leads to somatic hypermutation....

non-homologous end joining (NHEJ) of the DNA repair pathway. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen...

commonly repairs the damaged segment via non-homologous end joining (NHEJ). NHEJ involves the ligation of the damaged segments without using a homologous...

of the DNA are rejoined by a process called non-homologous end joining (NHEJ) to link the variable domain exon to the desired downstream constant domain...

Diplomacy and Trade in the Chinese World, 589-1276. Leiden, NLD: Brill, N.H.E.J., N.V. Koninklijke, Boekhandel en Drukkerij, 2005. p. 193. Bielenstein...

foreskin fibroblasts, one type of somatic cell, use non-homologous end joining (NHEJ), an error prone DNA repair process, as the primary pathway for repairing...

predicted micropeptide, MRI-2, may be important in non-homologous end joining (NHEJ) of DNA double strand breaks. In Co-Immunoprecipitation experiments, MRI-2...

terminal transfer, translesion synthesis (TLS), non-homologous end joining (NHEJ), and possibly in restarting stalled replication forks. Primases typically...

causes the cell to resort to the error-prone non-homologous end-joining (NHEJ) repair pathway, increasing the likelihood of incorrect repair of DNA breaks...

repair process of non-homologous end joining (NHEJ). WRN also physically interacts with the major NHEJ factor X4L4 (XRCC4-DNA ligase 4 complex). X4L4...

PMID 27499438. Martin MJ, Blanco L (July 2014). "Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition...

non-homologous end joining (NHEJ). Lig4 deficiency in the mouse causes a progressive loss of HSCs during aging. These findings suggest that NHEJ is a key determinant...

which cells respond to with repair mechanisms. Non-homologous end joining (NHEJ) directly ligates DNA from either side of a double-strand break where there...

"c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias". Mol. Cancer...

mechanism for repairing DNA double-strand breaks is non-homologous end joining (NHEJ), a mechanism that utilizes the DNA-dependent protein kinase (DNA-PK) complex...

repair (MMR), homologous recombination (HR), and non-homologous end joining (NHEJ). While hypoxanthine, or inosine when attached to a ribose, is a naturally...

similar to Nijmegen Breakage Syndrome include RAD50 deficiency and Cernunnos/NHEJ deficiency. NBS is caused by a mutation in the NBS1 gene, located at human...

PAM site, leading to indel mutations from the non-homologous end joining (NHEJ) pathway that can disrupt the recognition sequence, thereby preventing subsequent...

"c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias". Mol. Cancer...

joining (NHEJ) or homologous recombination (HR). A-type lamins promote genetic stability by maintaining levels of proteins that have key roles in NHEJ and...

which is composed of LCR sequence. NAHR and non-homologous end joining (NHEJ) within this region are responsible for a wide range of disorders, including...

in the direction of repair by the process of non-homologous end joining (NHEJ). The role of BRCA1-A appears to be to bind BRCA1 with high affinity and...

molecules are recruited via two different pathways: non-homologous end joining (NHEJ) pathway factors, which perform a similar religation function to that of...

"c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias". Molecular...

double-stranded DNA. It might additionally act as a connection between XRCC4 and other NHEJ factors (at DNA ends) When a mutation occurs in NHEJ1, then one sees that...

BRCA1 to promote lower fidelity DNA repair by non-homologous end joining (NHEJ). BRCA1 also colocalizes with γ-H2AX (histone H2AX phosphorylated on serine-139)...

prone to DNA damage and experience abnormalities in signaling for repair (NHEJ pathway), eventually leading to a replication failure and a permanent cell-cycle...

widely accepted. Later analyses were consistent with the involvement of NHEJ[clarification needed] in NUMT integration in humans. These processes occur...

of Watson and Crick DNA crosslinks – Nature, 2013 DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2 – Current Biology, 2002 A...

accompanied by at least four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure)...

cancer. The discoveries about Fanconi Anemia proteins, moreover, suggest that NHEJ inhibitors might help suppress Fanconi Anemia patients' predisposition to...

non-homologous end joining (NHEJ) pathway of DNA repair. Pol μ interacts with Ku and DNA ligase IV, which also participate in NHEJ. It is structurally and...

joining (NHEJ) or homologous recombination (HR). A-type lamins promote genetic stability by maintaining levels of proteins which have key roles in NHEJ and...

in the direction of repair by the process of non-homologous end joining (NHEJ). The role of BRCA1-A appears to be to bind BRCA1 with high affinity and...

chromosomes. It may be caused by a variety of factors. non-homologous end joining (NHEJ) nonrepetitive sequence Broadly, any nucleotide sequence or region of a genome...

in the direction of repair by the process of non-homologous end joining (NHEJ). The role of BRCA1-A complex appears to be to bind BRCA1 with high affinity...

to fix the break using one of two pathways: Non-Homologous End Joining (NHEJ) or Homology-Directed Repair (HDR). In the former method, the break is repaired...

apoptosis. As well, damage detection will mediate non-homologous end joining (NHEJ), producing an end-to-end fusion of double-stranded breaks. However, it is...

Subba Rao Kalluri (2006). "DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons". Neuroscience Letters. 393 (1): 18–22. doi:10...

recombinational repair (HR) pathway or by the non-homologous end-joining (NHEJ) pathway. NHEJ, although faster than HR, is less accurate. The early divergent step...

crucial when fixing double-stranded breaks via non-homologous end joining (NHEJ) in yeast. This repair mechanism is important for cell survival as well as...

"c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias". Mol. Cancer...

repair: nucleotide excision repair (NER) and non-homologous end joining (NHEJ) (see NEDD8). One or more DNA repair genes in seven DNA repair pathways are...

non-homologous end joining (NHEJ) pathway of DNA repair, active in repairing DNA double-strand breaks. This suggests an important role of NHEJ in longevity assurance...

non-homologous end joining (NHEJ). LMNA promotes genetic stability by maintaining the levels of proteins that have key roles in HR and NHEJ. Mouse cells that are...

CRISPR/Cas9 edits rely on double-strand breaks and non-homologous end joining (NHEJ) or homology-directed repair (HDR) to fix DNA breaks, while the prime editing...

Chen BP, Chen DJ (September 2006). "Role of non-homologous end joining (NHEJ) in maintaining genomic integrity". DNA Repair. 5 (9–10): 1042–8. doi:10...

(2017-09-20). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. Bibcode:2017Natur.549..548A...

exposes free dsDNA ends that are recognised as repair substrates by host NHEJ or HDR machinery, leading to illegitimate recombination and endogenization...

and characterised various components of the non-homologous end joining (NHEJ) system that repairs most DSBs in human cells. These studies also provided...

breaks (DSBs) and they continue, "error-prone nonhomologous end joining (NHEJ) repair in postirradiation cellular response, argues strongly against a DNA...

mechanisms of a cell: non-homologous end joining (NHEJ) and homology-directed repair (HDR). Repair through NHEJ comes about by the ligation of the end of the...

inaccurate DNA repair process termed alternative non-homologous end joining (A-NHEJ) that inaccurately repairs DNA damages such as those caused by the CRT. This...

association with at least four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure)...

mlr9623) instead of the usual one in each bacterial species. (Ku is involved in NHEJ repair.) Rhizobium galegae Jarvis, B. D. W.; Van Berkum, P.; Chen, W. X.;...

the action of RM-systems in bacteria, and the non-homologous end-joining (NHEJ) that follows the use of ZFN without a repair template. A major advance is...

protein kinase (DNA-PK) as being important in DNA non-homologous end joining (NHEJ), a pathway by which mammalian cells repair themselves. This discovery was...

has a role in repair of double-strand breaks. Non-homologous end joining(NHEJ) is a DNA repair pathway frequently used to repair DNA double-strand breaks...

sufficient to induce chromosomal aberrations, a hallmark of deficiency in NHEJ-mediated DNA repair. These properties implicate HMGA2 in the promotion of...

main pathways of DSB repair in eukaryotic cells: nonhomologous end joining (NHEJ) and homology-directed repair (HDR). Gene mutations or variation in expression...

stranded breaks (DSB) to promote nonhomologous end joining-dependent repair (NHEJ), immunoglobulin class-switch recombination (CSR), and fusion of unprotected...

UBE2L3 stabilizes 53BP1 and force cells to choose NHEJ to repair DNA double-strand break. Repair by NHEJ leads to radial chromosomes and cell death. UBE2L3...

randomly produces double-stranded breaks in the barcode regions and subsequent NHEJ repair introduces random indels, resulting in a unique DNA sequence at the...

DNA, including the less inaccurate pathway of non-homologous end joining (NHEJ) and accurate pathways using homologous recombinational repair (HRR). Various...

to human illnesses. In another example, the non-homologous end joining (NHEJ) protein repairs double-stranded DNA breaks and relies on the Ku70/Ku80 heterodimer...

PMID 17962301. Bennardo N, Cheng A, Huang N, Stark JM (June 2008). "Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair"...