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NCK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U5S, 1WX6, 1Z3K, 2B86, 2CIA, 2FRW, 2FRY, 2JXB, 4E6R
Identifiers
Aliases	NCK2, GRB4, NCKbeta, NCK adaptor protein 2
External IDs	OMIM: 604930; MGI: 1306821; HomoloGene: 20794; GeneCards: NCK2; OMA:NCK2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	105,894,274 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,609,675 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; parotid gland; ; secondary oocyte; ; Region I of hippocampus proper; ; ganglionic eminence; ; cartilage tissue; ; duodenum; ; olfactory zone of nasal mucosa; ; gums; ; gastric mucosa;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; thymus; ; lip; ; tail of embryo; ; yolk sac; ; primary visual cortex; ; spermatid; ; right kidney; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	scaffold protein binding; protein binding; cytoskeletal anchor activity; signaling receptor complex adaptor activity; phosphotyrosine residue binding; protein-containing complex binding;
Cellular component	cytosol; vesicle membrane; synapse; endoplasmic reticulum; cytoplasm; postsynaptic density;
Biological process	positive regulation of actin filament polymerization; epidermal growth factor receptor signaling pathway; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; actin filament organization; positive regulation of translation in response to endoplasmic reticulum stress; ephrin receptor signaling pathway; signal complex assembly; dendritic spine development; vascular endothelial growth factor receptor signaling pathway; positive regulation of T cell proliferation; negative regulation of peptidyl-serine phosphorylation; regulation of epidermal growth factor-activated receptor activity; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; immunological synapse formation; cell migration; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; T cell activation; regulation of translation; lamellipodium assembly; signal transduction; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8440
	17974
	ENSG00000071051
	ENSMUSG00000066877
	O43639
	O55033
	NM_001004720; NM_001004722; NM_003581
	NM_010879
	NP_001004720; NP_001004722; NP_003572
	NP_035009
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene.^[5]^[6]^[7]

Function

NCK belongs to family of adaptor proteins. There are two mammalian NCK genes, NCK1 and NCK2. NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]