The Missouri-Pacific Railroad built the station in 1906. In 1951, as "modernization", the hipped roof was removed and decoration stripped from the station, leaving a rectangular brick building.[2]
The Missouri-Pacific Railroad ended service on its Texas Eagle on April 30, 1971, one day before Amtrak took over passenger services. In March 1974, Amtrak's Inter-American was extended from Fort Worth to St. Louis, restoring passenger service to the Missouri-Pacific Railroad's main line but without a stop in Mineola.[1] The Inter-American was replaced by the Eagle in 1981, which in turn was renamed as the Texas Eagle in 1988.[1]
On April 14, 1996, Newport station in Arkansas was closed as part of a deal with the Union Pacific Railroad to reopen the stop at Mineola. Trains began stopping at Mineola on April 28.[1] According to Mineola native Willie Brown, the station was reopened as the result of his persistent lobbying of President Bill Clinton. Responding to an Amtrak report that a survey did not reveal anyone wanting to get off in Mineola, Brown reportedly told Clinton: "The reason to stop in Mineola is not to let anybody off. It's to let the people on. It's not that great a place. Look at me! I left!"[4] Amtrak, however, credited "Mineola community leaders" with the successful effort.[5]
In 2005, the city began an $800,000 renovation project, funded primarily by the Texas Department of Transportation, to restore the station to its original appearance. A new angled roof was constructed, signage and landscaping built, and the interior converted for use as a railway museum. The station was rededicated on June 10, 2006.[2]