Kalatozishvili (his surname at birth) was born in Tiflis, Russian Empire. His family belonged to a noble Amirejibi house that traces its history back to the 13th century. One of Mikhail's uncles served as a General in the Imperial Russian Army, another one was among the founders of the Tbilisi State University.
Kalatozov studied economics and changed many professions before starting his film career as an actor and later — as a cinematographer. He directed several documentary films, including Their Kingdom (with Nutsa Gogoberidze, the first Georgian female film director)[3] and Salt for Svanetia (1930).
Kalatozov was married to Zhanna Valachi, daughter of the Italian consul. They met in Batumi during vacation. In 1929 Zhanna gave a birth to their son Georgy and became a naturalized citizen of the Soviet Union. Georgy followed his father's steps and worked as a cinematographer and film director at the Kartuli Pilmi studio, and so did his grandson — Mikheil Kalatozishvili who also became a successful Russian film director and producer.
Mikhail Kalatozov died in Moscow on March 26, 1973 after his seventh heart attack and was buried at the Novodevichy Cemetery.[9] Mikheil Kalatozishvili founded a non-commercial Mikhail Kalatozov Fund named after his grandfather to help with film preservation and with funding of new movies.[10]