Methylenetetrahydrofolate reductase (ferredoxin)

Methylenetetrahydrofolate reductase (ferredoxin)
Identifiers
EC no.1.5.7.1
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In enzymology, a methylenetetrahydrofolate reductase (ferredoxin) (EC 1.5.7.1) is an enzyme that catalyzes the chemical reaction

5-methyltetrahydrofolate + 2 oxidized ferredoxin 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H+

Thus, the two substrates of this enzyme are 5-methyltetrahydrofolate and oxidized ferredoxin, whereas its 3 products are 5,10-methylenetetrahydrofolate, reduced ferredoxin, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 5-methyltetrahydrofolate:ferredoxin oxidoreductase. This enzyme is also called 5,10-methylenetetrahydrofolate reductase. This enzyme participates in one carbon pool by folate.

References

  • Clark JE, Ljungdahl LG (1984). "Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum". J. Biol. Chem. 259 (17): 10845–9. PMID 6381490.


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