Following is a list of senators of Vaucluse, people who have represented the department of Vaucluse in the Senate of France.

Senators for Vaucluse under the French Third Republic were:^[1]

• Frédéric Granier (1876–1882)
• Elzéar Pin (1876–1883)
• Alphonse Gent (1882–1894)
• Alfred Joseph Naquet (1883–1890)
• Eugène Guérin (1890–1920)
• Georges Taulier (1894–1899)
• Auguste Béraud (1900–1905)
• Achille Maureau (1905–1920)
• Louis Serre (1920–1936)
• Louis Tissier (1920–1936)
• Ulysse Fabre (1936–1940)
• Louis Gros (1936–1940)

Senators for Vaucluse under the French Fourth Republic were:^[2]

• Lucien Grangeon (1946–1948)
• Jean Geoffroy (1948–1959)
• Marcel Pellenc (1948–1959)

Senators for Vaucluse under the French Fifth Republic:^[3][4]