This is a list of Spanish football transfers for the summer sale prior to the 2021–22 season of La Liga. Only moves from La Liga are listed.
The summer transfer window will begin on 1 July 2021, although a few transfers were announced prior to that date, the transferred players will not officially become part of their new club until the window's opening. The window will close at midnight on 2 September 2021. Players without a club can join one at any time, either during or in between transfer windows. Clubs below La Liga level can also sign players on loan at any time. If needed, clubs can sign a goalkeeper on an emergency loan, if all others are unavailable.
Manager: Javier Calleja (2nd season)
Manager: Marcelino (2nd season)
Manager: Diego Simeone (11th season)
Manager: Ronald Koeman (2nd season)
Manager: Álvaro Cervera (7th season)
Manager: Eduardo Coudet (2nd season)
Manager: Fran Escribá (2nd season)
Manager: Vicente Moreno (2nd season)
Manager: Míchel (1st season)
Manager: Robert Moreno (1st season)
Manager: Paco López (5th season)
Manager: Luis García (2nd season)
Manager: Jagoba Arrasate (4th season)
Manager: Andoni Iraola (2nd season)
Manager: Manuel Pellegrini (2nd season)
Manager: Carlo Ancelotti (1st season)
Manager: Imanol Alguacil (4th season)
Manager: Julen Lopetegui (3rd season)
Manager: José Bordalás (1st season)
Manager: Unai Emery (2nd season)
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