Goofy-bunny Mr. Whiskers meets prissy-pooch Brandy Harrington within a cargo hold of a plane. When Whiskers mistakenly opens the hatch door, the pair is dropped into the Amazon Rainforest with no way home. Desperate and angry, Brandy makes a deal with the dictator lizard Gaspar: a way back to civilization in exchange for Mr. Whiskers as his dinner. In the end, she loses her way home, but truly gains a friendship with Lola Boa and Mr. Whiskers.

Brandy volunteers to watch a crocodile's eggs for the day, but when Lola Boa and the Toucan Twin sisters Cheryl & Meryl invite her to hang out, she leaves Whiskers in charge. It goes about as well as you expect, with Whiskers losing the eggs and mixing them up with those of other animals. Now he and Brandy must retrieve the correct babies to avoid Mama Croc swallowing them whole.

Spring is in the air as Whiskers falls in love for the first time: with a giant lizard, Isabel (Jennifer Hale). She wants nothing to do with the smelly rabbit, but Coach Brandy is determined that Whiskers can woo her. Meanwhile, Brandy has her own issues in fighting off a persistent little lemur (Charlie Adler & Jeff Bennett).

While out star-gazing, the gang meet the cosmonaut monkey Boris (Greg Baldwin), having crash-landed into the jungle. Though his shuttle comes equipped with a rescue signal button, he refuses to push it and have the humans return him to space. While Brandy schemes to call for her own rescue, Mr. Whiskers is having fun playing spaceman and thwarting her.

Mr. Whiskers, being bullied by a cruel neighborhood monkey, must find the confidence to stand up for himself before it drives him away from Brandy. Meanwhile, Brandy is on a mission to increase her public image in the jungle. Instead, she learns the importance of standing by your friends, even the uncool ones.

Brandy is hosting a girls-only slumber party and kicks Whiskers out, who forms one with Ed. Neither party is going too well until Whiskers begins a prank-war that quickly escalates into trouble for everyone.

Brandy wants to try to introduce fashion to the jungle. The jungle denizens proclaim Mr. Whiskers is a fashion genius.

It's Brandy's birthday though she is unhappy because it's her first birthday away from her family. She believes that it's also Whiskers' birthday as well.

Brandy is preparing for the Harrington Ball, which is a formal dance that the Harringtons have every year, but with all the hard work she forgot to get herself a date! She has Whiskers, and has to teach him some proper etiquette.

Brandy, disgusted with Gaspar's dictatorship, riles the jungle-dwellers to hold an election for king. She and Whiskers win the job, but quickly abuse the power just as bad as Gaspar, if not worse.

Brandy stumbles across a suitcase, finds a portable video game inside it, and she gives it to Mr. Whiskers to get him to stop bothering her. In the end, he finally has to save Brandy from falling off a cliff.

Brandy and Whiskers invite a jaguar named Lorenzo (Bobby Slayton) to stay with them, but he ends up driving them up the wall.

Mr. Whiskers accidentally crushes Lola's shedded skin with a boulder, leading him to believe he killed her and get inside her skin to prevent Brandy from discovering his (supposed) crime.

An ocelot named Artaro (Jeff Bennett) catches Brandy's fancy, and they fall in love and plan to go out on a date. Mr. Whiskers has a sneaking suspicion that Artaro is actually evil, and he tries to tell Brandy. Unfortunately Mr. Whiskers gets covered in tree sap and stuck on Brandy just before the date and when they both end up going out, Mr. Whiskers' assumptions about Artaro turn out to be true.

When Mr. Whiskers finds out about luck, he believes his feet will provide him with the luck he needs to remain safe and get anything he wants, much to Brandy's dismay.

Brandy introduces the concept of currency to the jungle and all hell breaks loose as a result.

When Brandy tells Mr. Whiskers to read something because he has too much time on his hands, she inadvertently leaves her diary out in the open, which Mr. Whiskers reads because of her suggestion. After a while this starts to devolve into him reading everyone else's diaries. In the end, Whiskers gets punished for violating his friends' privacy by being weaved into a spider-web, paralyzed by said spider's venom, dragged around, and weaved into a web again connected to his and Brandy's treehouse for the duration of the night.

Brandy is holding a food drive for the less fortunate, and Mr. Whiskers wants to help out; he ends up accidentally ruining it and getting kicked out. Whilst wallowing in self-pity, a superhero comic book blows in his face, leading Whiskers to become a superhero by the aliases of "Captain Fruity".

After Brandy realizes how difficult it is to wash clothes in the jungle, she sees Lola coughing. Brandy formulates a plan to pretend she is sick so she will receive such special treatment as well. Whiskers reads up on the "disease" that Brandy has, and tries to find a cure, which gets everybody but Brandy sick. She then has to cater to everybody's needs.

When Brandy and Mr. Whiskers try to eat the tastiest fruit in the jungle, Brandy finds out that the fruit tastes like dirty socks and only Whiskers likes it. As Brandy marches off in frustration, she kicks down an ant hill, leaving it exposed to anteaters who attack the hill on a regular basis. They then have to join the ant army.

When Brandy and Mr. Whiskers go to meet a new neighbor, a vampire bat named Vlad (Tom Kenny); Mr. Whiskers becomes scared because he believes that the creature is a vampire, despite the fact that nobody believes that Mr. Whiskers is correct.

While enjoying themselves at the river, Mr. Whiskers inadvertently crashes into Ed after Ed crashes into a log, which causes Mr. Whiskers to fly into a Mayan temple. Inside, they discover an ancient monkey's paw that grants wishes. Brandy, in frustration, wishes that she never knew Whiskers. She then forgets who Whiskers is.

Note: This episode is based on the short story "The Monkey's Paw" by W. W. Jacobs.

Brandy and Mr. Whiskers stumble across an old tree, which Brandy is of a rare kind that is capable of building a vessel capable of getting her back to Florida. The only problem: Mr. Whiskers becomes obsessed with protecting it.

Brandy prepares for a big coco ball match against Gaspar Le Gecko's team, which is the best in the jungle. However, despite her attempts to train the team, Ed the Otter keeps messing up and causes the team trouble. Brandy gets rid of Ed, but Gaspar has Ed for his team, and ends up winning the game on account of Ed's slip.

Brandy realizes that it's getting close to Christmas, so in an attempt to try to get back home, she spreads the word of Christmas to the Amazon, as she thinks Santa (Stephen Root) would have no choice but to come if people are looking forward to it. Unfortunately for her, Santa has her on the Naughty List for being cruel to Whiskers, giving her a piece of coal for her misdeeds. In her anger, she throws the coal at his reindeer (specifically Rudolph), causing him to crash. As a result, she, Whiskers, Lola, Cheryl, Meryl, and Ed take on his role to save the holidays.

Note: This episode is the only double-length special of the series, running for 22 minutes instead of the standard 10-11.

Brandy's life is shattered when her adoption papers state she's not a pedigree but a mixed breed or, in her case, a "common mutt". She drops into a rut, filled with depression and lack of proper grooming, and it's up to Whiskers to bring her back before the big beauty pageant. He does so, and Brandy wins the Pageant.

Mr. Whiskers leaves the treehouse after Brandy kicks him out, because of his sloppy behavior and becomes a son to a couple of Howler monkeys (Fred Willard and Tara Strong). Meanwhile, Brandy finds a new roommate, but realizes that she misses Mr. Whiskers so she rescues him from the Howler monkeys and the two make up for what they did as they return to the treehouse.

When Brandy has a red scarf and she wants to wear it to meet her friend's parents and tells Whiskers not to touch it (Or risk getting fed to the lions) Mr. Whiskers takes it without Brandy knowing and he messes it up when it goes into a volcano. Ed has an idea to weave a new scarf out of Whisker's fur, so they use bugs to shave it off (in the process he has to take off his jumpsuit), and a special formula to regrow his fur, however his fur keeps on growing longer and longer so he tries to fool Brandy into thinking it's growing strangely because he's old.

Someone in the jungle is stealing animals' possessions and everyone blames it on Brandy. Whiskers tries to clear her name.

A dog from Texas named Tiffany comes to the Amazon Jungle and becomes friends with Brandy. Whiskers tries to become friends with the two, but they reject him, leading him to build a poorly-constructed robot.

Brandy doesn't believe in the Easter Bunny and Mr. Whiskers tries to make her believe.

Brandy is jealous of Mr. Whiskers because he is a better leaf boarder than she is.

Mr. Whiskers walks into a swamp and comes out with two heads (Jeff Bennett), one being himself, and the other intelligent, a bit snooty, and speaking with the accent of a high-class British gentleman.

Mr. Whiskers gets tricked by buying goods with Gaspar's Gold Card (a parody of MasterCard).

Brandy saves Whisker's life, causing him to cater to her every whim.

Brandy and Mr. Whiskers have a picnic and encounter a baby peccary in the bushes. Brandy trusts Whiskers to take care of him, but the baby seems to copy every thing Mr. Whiskers does and causes the baby to behave more immature and rude.

Mr. Whiskers swallows a meteor, which causes him to sound like a radio. Everyone uses him for aerobics, exercise, entertainment and other things. He gets tired of people grabbing him and using him, so Brandy helps him.

After finding a suitcase of video equipment Brandy decides to make a video to send down the stream to help her get rescued. She and the rest of the jungle reenact the story of how she got stranded but find it too boring so Brandy ends up embellishing it.

By pulling out the "Root of Power", Whiskers becomes the new Grouter and is worshiped by a pack of Rodents. He believes that the root is what helps him accomplish everything he does in life and that he's nothing without it. Brandy thinks otherwise.

Brandy and Whiskers see a relationship therapist, Whiskers takes an exercise too far and pretends that he's Brandy, and vice-versa. Everybody believes this, except Brandy.

Mr. Whiskers' brain leaves his head to fulfill its own dreams.

Brandy and Whiskers get jobs at the Amazon Mall but Whiskers is the one that's doing all the work while Brandy just goofs off.

Brandy and Mr. Whiskers separate the treehouse into two sides because Whiskers is driving her nuts. He then wins a house make-over and throws a big party and keeping Brandy away from it, but when Brandy finally gets accepted she takes a bad step and ends up destroying the huge mansion.

Brandy enters a karaoke contest, but has a scratchy singing voice however the leaders of the contest seem to love it.

Whiskers tries to teach Wolfie manners so he won't mess up his date with Brandy.

Brandy steals a pair of expensive Bugley's shoes, but feels guilt for stealing them. (The title and the story are from Edgar Allan Poe's "The Tell-Tale Heart")

Dental hygiene sweeps the Jungle as Brandy buys white strips.

Mr. Whiskers joins a gang of tough meat-eaters that want to sink their teeth into Brandy.

Brandy's hair job goes wrong; after trying to turn her bad blue color back to blonde the mixture turns into a frizzy green mess. This causes her to become the most mocked person in the jungle.

Brandy and Mr. Whiskers train to be lifeguards but the job reveals that Brandy can't swim.

Whiskers and Ed fight over Margo.

Whiskers finds a new pet, then promptly loses it so Brandy gives him a little assistance.

Gaspar offers Brandy a dress in exchange for being his girlfriend while his mother comes to visit but it reveals that Gaspar's mother is a fraud and made the whole thing up to go out with Brandy this makes her explode so bad that she starts chasing Gaspar even when Whiskers figures he can solve it.

An annoying snail moves in under Brandy and Whiskers, claiming he was there the entire time they were. Whiskers' ball bounces into the snail's home, and the snail refuses to give it back.

Whiskers is revealed to have been a magician's rabbit, and Gaspar has found some magical socks which he starts using to threaten everyone in the jungle into doing what he wants. Whiskers then challenges Gaspar to a magic-off.

Brandy breaks her promise to go with Whiskers and help kids collect fireflies, and decides to go a Sugartoad concert.

Brandy auditions for a play, but her audition becomes ruined because Margo puts celtzer in her drink, which causes her to burp in between lines. She exacts revenge against her by teaming up with Gaspar, who, unbeknownst to Brandy, is Whiskers' understudy.

Brandy and Mr. Whiskers throw a party and the house is now a mess. So they call a professional cleaner called Auntie Dote.

Brandy accidentally purchases a cursed amulet but Whiskers actually loves it.

Gaspar cons Whiskers out of a Sugartoad poster for Meteor insurance, only Whiskers starts to regret the trade and tries to get it back. But which item does he need most?

Brandy plans a samba lesson with an admirer named Tito but can't get there because of the severe weather however Whiskers gives her a message from Tito saying that he had to cancel their lesson be he had to visit his mother Brandy is disgusted that Whiskers made her go all the way out there for nothing and then starts to nab him.

Brandy and Whiskers meet their perfect counterparts, Sandy & Mr. Frisky.

Gaspar and Brandy make a bet that Whiskers can build a fruit car and can come back in 24 hours.

Brandy and Whiskers audition to be cheerleaders.

Brandy wants to sign up for self-defense classes to protect herself and meet cute guys. Whiskers signs them up for every class except self-defense.

Whiskers finds an old toy that belonged to Brandy.

Brandy lies about having a rock-star boyfriend to go with her to Love-fest and has to pick up one quick.

Whiskers tries to solve Brandy's stress problem, but only makes matters worse.

Whiskers and Gaspar are too short to ride a rollercoaster, so they try to sneak in. They try everything but nothing works, so as a last resort, they start a size revolution.

Ed and Lola have a crush on each other, so Brandy tries to make the relationship perfect, while Whiskers tries to sabotage the whole thing.

Brandy hypnotizes Whiskers with a pinwheel, and he instantly begins cleaning whenever he hears the word pickle. Unfortunately, everybody in the jungle starts saying pickle.

While playing with Brandy's make-up, Whiskers gets a pimple and thinks he will turn into a monster.

When Mr. Whiskers finds a bag of shiny rocks, he and Brandy argue over what they should do with it.

When Whiskers decides to join Gaspar’s wrestling league, he makes Brandy his tag team partner.

Whiskers finds a book called "I Am Rainfo" and is constantly reading it. However, the cover is broken and it really is "In the Amazon Rainforest". Whiskers, trying to figure out what it is, learns that it is his home along with Brandy's. However, the sheer creepy creatures in the jungle causes him to live on a raft.

After being mocked by tortoises, Whiskers decides it's high-time to challenge one tortoise to a match to settle the tortoise and the hare story once and for all.

After Whiskers gets bitten by a frog that can make victims sleep for 50 years, he decides to make his last moments count before he goes into a half-century-long deep sleep.